tensin, a slight but not significant decline in cardiac contractility was observed. Activities of various intramitochondrial and extramitochondrial enzymes were measured in both groups. After alcohol administration, the primarily intramitochondrial isocitrate dehydrogenase diminished. ATP in heart muscle of dogs exposed to alcohol declined, and mitochondrial oxygen consumption and respiratory c...

A theory is proposed that biochemical changes at the synapse that occur as a result of stimulation of specific neuronal circuits can lead to long-term changes only if alterations occur in synaptic structures in these circuits. The main synaptic structure that is thought to undergo this alteration is the postsynaptic density (PSD). There are many reports in the literature of overall structural c...

We herein describe a Japanese family with distal hereditary motor neuropathy carrying a K141Q mutation of small heat shock protein HSPB1. Two patients among them had late onset disease (older than 50 years). The muscles of the distal legs were weak and atrophic. Sensory and autonomic dysfunction were not seen. Even eight years after onset, one patient could still walk without support. A nerve c...

A proposed theory for the development of bmmhial asthma suggests the presence of partial or complete blockage of the beta-adrenergic nervous sy~ tem. l~~ Evidence to support this hypothesis stems from observations that individuals with bronchial astbma have increased sensitivity to beta-adrenergic blocking agents, as well as specific pharmacologic, physiologic and biochemical alteration~.~-~ Th...

We present a case of a 65-year-old man with an acute alteration in mental state that was initially diagnosed as a functional psychiatric condition. After extensive workup, herpes simplex virus type 1 (HSV-1) was detected in the patient's cerebrospinal fluid (CSF) by polymerase chain reaction (PCR), and he responded rapidly to treatment with acyclovir. The case illustrates the importance of acti...

Chronic obstructive pulmonary disease is an inflammatory disease. Together with oxidant stimuli, which directly affect lung structures, macrophages, neutrophils and CD8+ lymphocytes actively participate in the pathogenesis of the disease and promote biochemical reactions that result in progressive alteration of the upper airways and irreversible lung remodeling. The release of substances promot...

A hypothesis is presented that electronic and vibrational resonant energy states are important in biochemical reactions due to their coupling to hydrogen transfer reactions. The hypothesis is based upon (1) the involvement of hydrogen in most biochemical reactions, (2) the unique abiity of hydrogen to act as an energy trap for resonant energy and (3) demonstrations of the coupling of resonant e...

Fixation is usually the first step to prepare biological specimens for microscopy. Any treatment which will preserve cell structure and its biochemical composition can be deemed to be fixation. Of course, the quality of fixation is the key for all following steps which are necessary in histological research. Hence, preservation of cells with minimal alteration of morphology and virtually no los...

Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we describe recent technical developments and applications of residue-specific incorporation to problems ranging from elucidation of biochemical mechanisms to engineering of protein-based biomaterials. We hope to inform the reader of the ease ...

Dengue is an important mosquito-borne viral infection[1-3]. This infection can be seen in many tropical countries and caused many infectious cases annually. Based on its pathogenesis, the alteration of physiology can be seen and this can affect laboratory findings[4]. The biochemical profile change during infection is very interesting. Here, the authors studied on a rarely mentioned parameter, ...