نتایج جستجو برای: bioavailable

تعداد نتایج: 3626  

2013
Charles T. Price Kenneth J. Koval Joshua R. Langford

Physicians are aware of the benefits of calcium and vitamin D supplementation. However, additional nutritional components may also be important for bone health. There is a growing body of the scientific literature which recognizes that silicon plays an essential role in bone formation and maintenance. Silicon improves bone matrix quality and facilitates bone mineralization. Increased intake of ...

2012
Michael Lainchbury Thomas P. Matthews Tatiana McHardy Kathy J. Boxall Michael I. Walton Paul D. Eve Angela Hayes Melanie R. Valenti Alexis K. de Haven Brandon Gary Box G. Wynne Aherne John C. Reader Florence I. Raynaud Suzanne A. Eccles Michelle D. Garrett Ian Collins

Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridization of two lead scaffolds derived from fragment-based drug design...

2018
Serena Lima Conner L Webb Evelyne Deery Colin Robinson Julie A Z Zedler

Dietary supplements and functional foods are becoming increasingly popular complements to regular diets. A recurring ingredient is the essential cofactor vitamin B12 (B12). Microalgae are making their way into the dietary supplement and functional food market but do not produce B12, and their B12 content is very variable. In this study, the suitability of using the human B12-binding protein int...

Journal: :The American journal of clinical nutrition 1988
J A Vinson P Bose

This study was performed to determine whether synthetic ascorbic acid (AA) alone or in a natural citrus extract containing bioflavonoids, proteins, and carbohydrates was more bioavailable to human subjects. The effect of a single 500-mg ascorbate dose of the two forms and a placebo citrus extract on plasma ascorbate was examined in eight fasting subjects. A comparison of the areas under the pla...

Journal: :Proceedings of the National Academy of Sciences 2013

Ahmad Amir Abadi Farhani Morteza Beyki Bandar Abadi Nematollah Dayyani,

Chelating is the chemical process by which a mineral (iron, cobalt, copper, zinc, and manganese) is combined with a mixture of amino acids and peptides. The resulting substances are known as chelates. Another descriptive term, proteinates, refers to the amino acid bond. These chelated minerals are thought to be more digestible than nonchelated forms. In other words, chelation makes the minerals...

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