The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of aceclofenac by transdermal and oral application. Nanoemulsion, nanoemulsion gel and marketed tablet (Aceclofar®) were subjected to pharmacokinetic (bioavailability) studies on Wistar male rats. Several pharmacokinetic parameters like Cmax, tmax, AUC0→t, AUC0→α, Ke, and T1/2 were determined for each ...

Objective: Buccal drug delivery is the most suited route for local as well systemic of drugs. Cilnidipine an L/N type dihydropyridine 4th generation calcium channel blocker (CCB), which decreases hypertension by blocking N-type to attenuate vascular sympathetic neurotransmission. It has high first-pass metabolism leading low bioavailability. Hence present research work was undertaken formulate ...

The current study was aimed to design a thiolated chitosan (TC) based mucoadhesive nanoparticle (NP) formulation for enhancing the oral bioavailability of an anti-coagulant, Ticagrelor (TG). Nanoparticles (NPs) containing naturally occurring biodegradable polymers have been revealed as promising carriers controlled delivery various therapeutic agents through route. Ionic gelation technique adop...

Over several centuries, oral dosage forms have remained incomparably superior to alternative medication delivery methods. For its ease of formulation and administration, stability, excellent rate patient compliance, the route is preferred. Gastric emptying has been a major drawback for drugs that stay very short period in stomach. An innovative method gastro-intestinal retention allows form gas...

Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of p...

Keyphrases D Pharmaceutical salts-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Salts, pharmaceutical-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Physicochemical properties-dissolution, solubility, stability, and organoleptic properties of pharmaceutical salts,...

Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis re...