In response to increased evidence of ecosystem damage by toxic antifouling paints, many researchers have developed nontoxic silicone fouling release coatings. The fouling release capability of these Systems may be improved by adding nonbonding silicone oils to the coating matrix. This idea has been tested by comparing the adhesion strength of hard- and soft-fouling organisms on a cured polydime...

A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hy...

Different non-ionic cellulose ethers (methyl cellulose, MC; hydroxyethyl cellulose, HEC; hydroxypropyl cellulose, HPC; hydroxypropylmethyl cellulose, HPMC) and microcrystalline cellulose (MCC) were investigated as matrix formers for preparation of mini-tablets targeting vaginal drug delivery. Hexyl aminolevulinat hydrochloridum (HAL) was used as a model drug. The mini-tablets were characterized...

Dihydroxyphenylalanine (DOPA) and similar molecules are of considerable interest in studies of bioadhesion to minerals, solar cells involving titanium dioxide, and biomedical imaging. However, the extent and mechanisms of DOPA adsorption on oxides in salt solutions are unknown. We report measurements of DOPA adsorption on well-characterized rutile (α-TiO₂) particles over a range of pH, ionic st...

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir...

The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly & then maintain the desired drug concentration. That is why the drug delivery system should deliver dr ug at a state dictated by the needs of the body over a specified period of treatment. This idealized objective points to the two aspects most important to drug del...

the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

The risk of developing skin cancer from ultraviolet radiation (UVR) can be mitigated with sunscreens. Safety and aesthetic concerns about commercial sunscreens have led to our development a bioadhesive nanoparticle (BNP) sunscreen platform. Building upon prior work encapsulating FDA-approved agents avobenzone octocrylene, we now also encapsulated EU-approved diethylamino hydroxybenzoyl hexyl be...

Carboxylated polystyrene microspheres with 1 μm in diameter were surface-modified either by coating with poly(ethyleneimine) (PEI) as cationic polyelectrolyte leading to a conversion of the surface charge from negative to positive, or by covalent immobilization of wheat germ agglutinin (WGA) via a carbodiimide method to obtain a carbohydrate specific biorecognitive surface. To characterize the ...