The potency, selectivity, and decreased side effects of bioactive peptides have propelled these agents to the forefront of pharmacological research. Peptides are especially promising for the treatment of neurological disorders and pain. However, delivery of peptide therapeutics often requires invasive techniques, which is a major obstacle to their widespread application. We have developed a tai...

Bioactive molecules (or signaling molecules) are involved in tissue regeneration and have an important role modulating the microenvironment vivo. chemicals ability to govern host cell motility, proliferation, differentiation, as well enabling cells interact with their surrounding via particular receptors for chemical recognition. This chapter introduces ion-exchange chromatography (IEC) a metho...

Background Bioactive peptides prospection is important for biotechnology field as well as a starting point in many research areas, such as: new drugs development and production of genetically modified plants [1]. In general, bioactive peptides have been identified as candidates for the new drugs development because their intrinsic properties concerning some potential activities, like high speci...

Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals ...

A total number of 210 strains of lactobacilli were isolated from different sources – homemade yoghurts and cheeses, plants and human fecal samples. The species affiliation of the strains was analyzed by Amplified Ribosomal DNA Restriction Analysis (ARDRA) followed by 16S rDNA sequencing. The strain differentiation was obtained by methods of Pulsed Field Gel Electrophoresis (PFGE) and Amplified ...

In earlier work, we have provided direction for development of responsive drug delivery systems based on modulation of structure and amphiphilicity of bioactive peptides entrapped within pendant polyethylene oxide (PEO) brush layers. Amphiphilicity promotes retention of the peptides within the hydrophobic inner region of the PEO brush layer. In this work, we describe the effects of peptide surf...

Ovalbumin-derived peptides IFYCPIAIM, NIFYCPIAIM and YCPIAIMSA, containing a common region YCPIAIM, were previously identified as aggregation-prone with variable fibril formation. In this study, we elucidated self-assembly mechanisms of the peptides, by determining influence on sulfhydryl group accessibility. The free content antioxidant capacity results demonstrate that assemble into β-sheets,...

A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs because they contain only short open reading frames (sORFs). Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show that peptides of 11 to 32 amino acids encoded by the polished rice (pri) sORF gene control epidermal differentiation in Drosophila by modifying the tran...

Bioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of enzymes--a disulfide bond generating enzyme, a disulfide bond donor enzyme and a redox cofactor--that function inside the cell dictates the formatio...

The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are descr...