Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and Escherichia coli [minimal inhibitory c...

A near-shore marine intertidal environment-associated Streptomyces isolate (USC-633) from the Sunshine Coast Region of Queensland, Australia, cultivated under a range of chemically defined and complex media to determine optimal parameters resulting in the secretion of diverse array of secondary metabolites with antimicrobial properties against various antibiotic resistant bacteria. Following ex...

The aim of the present study was to isolate hepatoprotective component from Urtica dioica Linn. (whole plant) against CCl4-induced hepatotoxicity in-vitro (HepG2 cells) and in-vivo (rats) model. Antioxidant activity of hydro alcoholic extract and its fractions petroleum ether fraction (PEF), ethyl acetate fraction (EAF), n-butanol fraction (NBF) and aqueous fraction (AF) were determined by DPPH...

Sepsis is a life-threatening condition that requires urgent medical attention. In this study, we investigated the potential of soybean-derived peptides (soy peptides) as an anti-inflammatory supplement for patients with sepsis. Cynomolgus monkeys were induced sepsis by intravenous administration three different concentrations Escherichia coli (6.3 × 103, 6.3 105, and 107 CFU/kg). Changes in bod...

Itaconic acid is one of industrially important organic produced by fungi. It an unsaturated dicarboxylic acid, which can be used as a replacement for petroleum base chemicals. monomer in synthesis biodegradable polymer such fibre, plastics, detergents, rubber, lubricants and bioactive compounds. In this study, thirty five fungal isolates were retrieved from soil samples collected different site...

Background: Marine seaweeds synthesize different metabolites with various biological activities, including antimicrobial effects. Objectives: The main object of this study was to fractionate the seaweed Padina australis and analyze activities these fractions isolate bioactive compounds. Methods: collected from Persian Gulf extracted by maceration methanol-ethyl acetate solvent. extract evaporat...

Plant-parasitic nematodes form one of the largest sources of biotic stress imposed on plants, and are very difficult to control; among them are the obligate parasites, the sedentary root-knot nematodes (RKNs)-Meloidogyne spp.-which are extremely polyphagous and exploit a very wide range of hosts. Endophytic fungi are organisms that spend most of their life cycle within plant tissue without caus...

The charge-transfer (CT) together with the polarization energy appears at second and higher orders in symmetry-adapted perturbation theory (SAPT). At present there is no theoretically compelling way of isolating the charge-transfer energy that is simultaneously basis-set independent and applicable for arbitrary intermolecular separation. We argue that the charge-transfer can be interpreted as a...