Here, we investigated the potential mechanism of capsaicin-mediated apoptosis in pancreatic cancer cells. Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells. The expression of BIM increased in response to capsaicin treatment. Capsaicin treatment caused cleavage of caspase-3 and PARP, indicati...

Following the launch of the Government Construction Strategy in 2011, the UK construction sector has witnessed a significant increase in the awareness and adoption of Building Information Modelling (BIM). As recognised by the strategy, there are synergies between Lean Construction and BIM. BIM implementation demands changes in existing process and procedures for design and construction, represe...

PURPOSE Statins are known to have pleiotropic effects that induce cell death in certain cancer cells. BIM is a member of the bcl-2 gene family, which promotes apoptotic cell death. This study investigated the hypothesis that simvastatin has pro-apoptotic effects in epidermal growth factor receptor (EGFR)-mutated lung cancer cell lines via the upregulation of the expression of the BIM protein. ...

Building Information Model (BIM) encompasses mass of data specified by Industry Foundation Classes (IFC) from multiple fields during the whole lifecycle of the Architecture, Engineering and Construction (AEC) project. Recently, a large international initiative is launched to provide extensive support that will facilitate the creation, sharing and integration for BIM through all professions in t...

Building Information Modelling (BIM) is a remarkable development that has recently engulfed the construction sector globally. It has provided a catalytic means for “rethinking” the design, construction, and operation of our built environment. Fundamentally a technology driven concept, BIM when entwined with issues pertaining to people, processes and organizations has the potential to significan...

Although PD-1 blockade therapy demonstrates promising therapeutic effects in a portion of metastatic melanoma patients, clinical outcomes remain variable, with some patients achieving durable responses, others experiencing early disease worsening followed by later tumor reduction, while some show no benefit. Thus, it is critical to identify patients with melanoma who are most likely to benefit ...

The physiological role of B cell lymphoma 2 (Bcl-2) homology 3-only proteins has been investigated in mice lacking the individual genes identifying rate-limiting roles for Bim (Bcl-2-interacting mediator of cell death) and Puma (p53-up-regulated modulator of apoptosis) in apoptosis induction. The loss of Bim protects lymphocytes from apoptosis induced by cytokine deprivation and deregulated Ca+...

The process of capturing and modelling buildings has gained increased focus in recent years with the rise of Building Information Modelling (BIM). At the heart of BIM is a process change for the construction and facilities management industries whereby a BIM aids more collaborative working through better information exchange, and as a part of the process Geomatic/Land Surveyors are not immune f...

With the use of Building Information Models (BIM), realtime 3D visualizations have become a natural tool in order to communicate ideas and share information between all involved parties in a project. Currently, several different BIM viewers are available for the purpose of interactive presentations and design reviews. However, as BIMs become larger and more detailed, it provides a challenge for...

Positive and negative selection of thymocytes in the thymus are critical for the development of a mature and self-tolerant T-cell repertoire. The proapoptotic Bcl-2 family member Bim is important for negative selection by inducing apoptosis in thymocytes receiving a strong signal through their antigen receptor. However, in the case of ubiquitous self-antigens (UbA), Bim is not required for the ...