BACKGROUND: Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluids. Among them, bilirubin, uric acid and protein thiols are the major endogenous antioxidants, while vitamins C and E, as well as a number of food-derived (poly)aromatic substan...

The aim of our study is to examine the levels of routine biochemical markers in patients with major depressive disorder (MDD), and combine multiple biochemical parameters to assess the discriminative power for patients with MDD. We used the Hamilton Depression (HAMD) score to evaluate the severity of depressive symptoms in 228 patients with MDD. The phase of depression severity was between mode...

background: efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. this study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (tls) of leukemia and lymphoma patients.materials and methods: the study was done with a retrospective cohort design. patients we...

introduction: controlling and reducing serum uric acid levels may have beneficial effects on blood pressure control. the current study was carried out to assess the effects of allopurinol administration on serum uric acid and arterial blood pressure among the patients under hemodialysis.  methods: this double-blind clinical trial was conducted on 132 hemodialysis patients (two separate groups) ...

Increasing the level of urea and uric acid is an associated complication of diabetes mellitus. Many spices and herbs are known to be hypoglycaemic. Olea europaea belonging to the family oleaceae is widely used in herbal medicine for the treatment of diabetes. The present study was carried out to investigate the role of the alcoholic extract from leaves of olive on level of urea and uric acid in...

Background: Garcinia kola seed is consumed indiscriminately in Nigeria without recourse to its potential toxicity. Therefore, this study was aimed at assessing the toxicity of the aqueous extract of G. kola seeds on selected tissues of male rats.  Methods: Thirty male rats (215.00 ± 18.58 g) were assigned into four groups: A, B, C and D which received 0.5 ml of distilled water, 2...

background: although the issue of hyperuricemia as a risk factor for cardiovascular diseases (cvd) has been disputed, sev­eral studies have shown an association between hyperuricemia and   several cvd risk factors. the aim of this study was to assess distribution of uric acid level in yazd city, center of iran, and its association with cvd risk factors. methods: from autumn 2004 to summer 2005,...

The rise of temperature following typhoid vaccination is accompanied by a marked increase in the output of total nitrogen, creatinin, and especially of uric acid. The reaction to tuberculin is slower, but is also accompanied by an increased output of nitrogenous substances, that is, however, less uniform and generally less pronounced. In a case of malaria there was a tendency for the rise of te...