Granuloma annulare represents a reaction pattern that is recognized as idiopathic in many cases but is attributed to a variety of inciting factors in some cases. In this report, we present a case of granuloma annulare-like pattern reaction to tattoo pigment.

In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking hydrazone Isatin to via methylene group formaldehyde. new compounds characterized using FT-IR spectroscopy, 1H-NMR spectroscopy the physical properties.

The catalytic ability of ZrO(2)/SO(4)(2-) to promote solventless three-component condensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethyl acetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the same reactants but different temperature conditions. The sulfat...

Some aromatic aldehydes are subjected to react with urea (or thiourea) and acetyl acetone in a one-pot Biginelli-type cyclocondensation reaction to give 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro-pyrimidines 2a-j. Aldehydes with ortho-hydroxy substituent namely salicylaldehyde and 2-hydroxy-3-methoxybenzaldehyde undergo Michael-type addition of the hydroxyl-proton to the C5−C6 double bond of t...

The absolute configuration of three 4-aryl-3, 4-dihydro-2(1H)-pyrimidones (Biginelli compounds, DHPMs) was established by comparison of the typical circular dichroism (CD) spectra of individual enantiomers with reference samples of known absolute configuration. The enantiomers were obtained by semipreparative separation of racemic mixtures on a Chiralcel OD-H chiral stationary phase. The method...