The voltage-gated calcium channel (VGCC), CACNA1A, is associated with several neurological disorders, including familial hemiplegic migraine, episodic ataxia type 2, epilepsy, and spinocerebellar ataxia type 6 (SCA6). CACNA1A encodes the Cav2.1 (α1A) subunit, the main pore-forming subunit of the P/Qtype VGCC, responsible for the Ca currents that mediate transmitter release in many CNS synapses....
