using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. the system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. the system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

The carbon isotopic fractionation of phytoplankton photosynthesis ( p) has been interpreted by previous authors as inconsistent with active bicarbonate uptake. This interpretation contradicts the results of numerous physiological studies demonstrating signi cant active bicarbonate uptake in phytoplankton. Using a simple model of cellular regulation of carbon acquisition we show that an upward c...

Methods Data from Auckland children with newly diagnosed T1DM between 1 January 2000 and 31 December 2009 were collected from Starbase, the Starship Children’s Hospital diabetes database. T1DM was confirmed by the presence of glutamic acid decarboxylase and/or tyrosime phosphatise-like protein (IA2) antibodies. DKA was defined by international criteria as venous or capillary pH and bicarbonate ...

in the present study, the soil and water assessment tool (swat 2000) model was tested on both a monthly and yearly basis and applied to the kordan watershed, located in iran. the main objective of the research was to assess the accuracy of the model in sediment-yield and surface water bicarbonate concentration estimation. the attributes of sub-watersheds, tributary channels and the main channel...

In patients on long-term continuous ambulatory peritoneal dialysis, the efficiency of dialysis declines because of peritoneal neovascularization and loss of peritoneal mesothelial cells. In this study, we investigated the influence of lactate and bicarbonate in peritoneal dialysis fluid on such changes of the peritoneum. We studied the production of vascular endothelial growth factor (VEGF) and...

Metabolic acidosis is a condition that is commonly encountered in both chronic renal failure and in end-stage renal disease. Metabolic acidosis is associated with many adverse effects: negative nitrogen balance, increased protein decomposition, anorexia, fatigue, bone lesions, impaired function of the cardiovascular system, impaired function of the gastrointestinal system, hormonal disturbances...

The transport of sulfate was studied in basolateral membrane (BLM) vesicles isolated from rat kidney cortex by centrifugation on a Percoll self-generating gradient. In contrast to sulfate transport at the luminal membrane, sulfate uptake by BLM vesicles was not sodium dependent. However, imposition of an inside greater than outside bicarbonate gradient stimulated BLM sulfate uptake nearly 10-fo...

Butyric acid is detected in periodontal pockets and is thought to be involved in the initiation and progression of periodontal disease. We examined the effects of sodium bicarbonate on the butyric acid-induced epithelial cell damage. The human gingival carcinoma cell line Ca9-22 was cultured in medium that contained butyric acid with or without sodium bicarbonate. The viability of cells treated...

The present studies were designed to explore the possible mode of protective and ulcer healing actions of sucralfate by examining its effect on gastroduodenal bicarbonate secretion by isolated amphibian mucosa. Luminal sucralfate (0.5 g/l) significantly increased bicarbonate secretion by fundic and antral mucosa without influencing transmucosal potential difference. Significant stimulation of d...

Introduction Hyperpolarized (HP) [1-C]pyruvate has been shown to be metabolized to [C]bicarbonate and other products both in vivo and in isolated perfused hearts. The appearance of a [C]bicarbonate signal following an injection of hyperpolarized [1-C]pyruvate reflects the activity of pyruvate dehydrogenase (PDH) in heart. In some metabolic circumstances, the [C]bicarbonate signal is low and con...