The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells. Results showed that intestinal cells expressed only the SR-BI isoform with little or no expression of the SR-BII variant. The expression of SR-BI in Caco-2 cells is differentiation dependent, with little or no expressio...

Business Intelligence (BI) project failure rates are high and expected benefits are not always achieved when implementing a BI solution in an organization. Failure is characterized by recurring challenges that remain largely unresolved. Could a better understanding of BI and its challenges emerge by taking a step back to examine how BI is understood? To answer this overarching research question...

Purpose – The purpose of the paper is to provide a thorough analysis of the difference between business intelligence (BI) and knowledge management (KM) and to establish a framework for relating one field to the other. Design/methodology/approach – A review of the literature from approximately 1986 through 2004 served as the basis for analysis and comparison of BI and KM. The theoretical scope o...

While IS success research has gained considerable attention within academia in the past, understanding its constituents and the relationships among them has also emerged within professional fields. Since extant inquiries on the relationships among IS success dimensions have produced equivocal findings, the need to address IS success in the context of specific technologies has been regularly hig...

Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown. SR-BI deficiency resulted in elevated VLDL cholesterol levels, both on chow diet and upon challenge with high-cholesterol diets. To specifically elucidate the role of SR-BI in VLDL ...

The Cu-Bi system exhibits nearly no solubility of Bi in Cu along with the highest solute boundary enrichment factor among metal systems making the Cu-Bi system ideal for segregation studies [1]. Cu-Bi also shows a high degree of segregation induced grain boundary embrittlement. The precise cause of this embrittlement has been attributed to Bi size effects along the Cu boundary or modification o...

Safety, tolerability and pharmacokinetics of BI 409306, a potent and selective phosphodiesterase 9A inhibitor, were assessed in healthy subjects in three Phase I, within-dose group, double-blind trials. Trial 1 randomised young and elderly subjects to receive BI 409306 25, 50, 100 mg, placebo once daily (OD) or BI 409306 50 mg twice daily (young) for 14 days. Trial 2 randomised young poor metab...

This study examined the specificity of disgust in predicting avoidance in blood/injury (BI) phobia. Participants high (n=38) and low (n=46) in BI fear completed measures of disgust across multiple domains and severity of BI-related fear. They then completed three randomly presented behavioral avoidance tasks (BATs) that consisted of exposure to a 15'' severed deer leg (BI task), a live spider (...

OBJECTIVE The high-density lipoprotein (HDL) receptor scavenger receptor Class B type I (SR-BI) plays a key role in mediating the final step of reverse cholesterol transport. This study examined the possible regulation of hepatic SR-BI by phosphatidylinositol-3-kinase (PI3K), a well known regulator of endocytosis and membrane protein trafficking. METHODS AND RESULTS SR-BI-dependent HDL select...

Users of Business Intelligence (BI) systems have started to demand more flexible systems in which they could be empowered to serve themselves – self-service BI. In this paper we aim at explaining how such development influences designers of BI solutions and how it impacts the design situation. To say something about this we adapted the PACT (People, Activity, Context, Technology) framework on t...