نتایج جستجو برای: bche
تعداد نتایج: 518 فیلتر نتایج به سال:
The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten derivatives were synthesized and evaluated for inhibitory activities against acetylcholinesterase (AChE) butyrylcholinesterase (BChE) by Ellman’s method. Most tested showed higher on BChE than AChE, however, their overall activity weak. In contrast, three (compounds 3,6,9) good AChE m...
Human butyrylcholinesterase is a performant stoichiometric bioscavenger of organophosphorous nerve agents. It is either isolated from outdated plasma or functionally expressed in eukaryotic systems. Here, we report the production of active human butyrylcholinesterase in a prokaryotic system after optimization of the primary sequence through the Protein Repair One Stop Shop process, a structure-...
MicroRNAs (miRs) have emerged as important gene silencers affecting many target mRNAs. Here, we report the identification of 244 miRs that target the 3'-untranslated regions of different cholinesterase transcripts: 116 for butyrylcholinesterase (BChE), 47 for the synaptic acetylcholinesterase (AChE-S) splice variant, and 81 for the normally rare splice variant AChE-R. Of these, 11 and 6 miRs ta...
In Alzheimer's disease (AD), premature demise of acetylcholine-producing neurons and the consequent decline of cholinergic transmission associate with the prominent cognitive impairments of affected individuals. However, the enzymatic activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are altered rather late in the disease progress. This raised questions regarding the ca...
In this work, previously synthesized tetra-chalcone-substituted metallophthalocyanines (MPcs) containing Ni(II), Zn(II), Co(II), and Cu(II) in the inner core were investigated anticholinergic activities against Alzheimer's disease (AD). The MPcs evaluated for their inhibition of acetylcholinesterase (AChE) butyrylcholinesterase (BChE) using original Ellman's colorimetric procedure. Against thes...
Nineteen tosylated acyl hydrazone derivatives were synthesized, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), β-secretase (BACE-1) evaluated. Compound 3o was the most potent inhibitor of MAO-A, with an IC50 value 1.54 µM, followed by 3a (IC50 = 3.35 µM). A structural comparison indicated that 3-F group in increased ...
BACKGROUND Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum albumin (hSA) and characterize the fusion protein. RESULTS Secretion level of the fusion protein p...
BACKGROUND Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites. RESULTS Microbial transformation of DHT (1) by using two fungal cultures resulted in potent butyrylcholinesterase (BChE) inhibitors. Biotransformat...
Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents worki...
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