In the present study, the effect of vitamin E (alpha-tocopherol) on mice skeletal muscle mitochondrial dysfunction and oxidative damage induced by an in vivo acute and severe hypobaric hypoxic insult (48 h at a barometric pressure equivalent to 8500 m) has been investigated. Male mice (n=24) were randomly divided into the following four groups (n=6): control (C), hypoxia (H), vitamin E (VE; 60 ...

The use of phytochemicals is gaining increasing attention for treating cancer morbidity with minimal burden side effects. This study evaluated the cytotoxicity and antimicrobial activities Pinus roxburghii branch (P. roxburghii) Nauplius graveolens (N. graveolens) extracts in vitro. Cell viability was estimated using MTT assay. DNA fragmentation determined to detect apoptotic pathway initiation...

Gastrin plays a vital role in the development and progression of gastric cancer (GC). Its expression is up-regulated GC tissues several cell lines. Yet, underlying mechanism remains to be investigated. Here, we aim investigate gastrin proliferation. Gastrin-overexpressing model was constructed using SGC7901 cells. Then differentially expressed proteins were identified by iTRAQ analysis. Next, u...

Background & Objective The current study aimed to perform an immunohistochemical analysis of patterns of apoptotic and cell proliferative related protein expression in different histological grades and immune phenotypes of malignant lymphomas and other lymphoproliferative disorders. Methods This observational study was carried on 60lymph node biopsies of lymphoproliferative disorders. The bio...

Yiqi Yangyin complex (YYC), the homology of medicine and food, is comprised Polygonati Rhizoma, Lycii Fructus, Codonopsis Pilosula, Rehmanniae Radix. Herein, YYC polysaccharide treatment effectively attenuated progression MGH in a mice model-induced with estrogen progestogen. significantly relived hormonal disorders by reducing levels receptor α (ERα) progesterone (PR), substantially elevated p...

Excessive environmental exposure to manganese (Mn) is associated with neurotoxicity and can produce Parkinson’s disease (PD)like neurological disorders. Although the molecular mechanism is not fully described, Mn-induced neuronal cell death is central to Mn neurotoxicity. The present study was designed to determine the effects of Dendrobium alkaloids (DNLA), a Chinese medicinal herb extract, on...

The present study aimed to investigate the molecular mechanisms of cyclic stretch-induced apoptosis in human intervertebral disc cartilage endplate-derived stem cells (CESCs). CESCs were stretched by the Flexercell-4000™ Tension Plus system, the effect on cell viability was measured by a Cell Counting Kit-8 assay, while cell apoptosis was detected by flow cytometry. Western blot analysis was us...