Vero cells were grown adherent to microcarriers (Cytodex 1; 3 g L(-1)) using animal component free media in stirred-tank type bioreactors. Different strategies for media refreshment, daily media replacement (semi-batch), continuous media replacement (perfusion) and recirculation of media, were compared with batch cultivation. Cell densities increased using a feed strategy from 1×10(6) cells mL(...

Batch distillation is an important separation process for small-scale production especially in pharmaceutical, specialty chemical and biochemical industries. Although batch distillation units require lower capital cost than continuous units, the unsteady state nature of the process, results in higher operating costs. Optimal control in batch distillation is a mode of operation which allows us t...

A mathematical model for fed-batch culture of hybridoma cells [24] has been employed for generating simulation data in this study. The model is a seventhorder nonlinear model where both glucose and glutamine concentrations are used to describe the specific growth rate, μ. The cell death rate, kd, is governed by lactate, ammonia and glutamine concentrations. The specific MAb production rate, qMA...

Ferritin is a macromolecule and is responsible for the long term iron storage function in human serum and plasma. Recent studies have highlighted the role of cell phone exposure on central nervous system, immune function and reproduction. The aim of this study was to investigate whether the human serum ferritin level could be interfered by the exposure to the 900 MHz GSM cell phones. Fifty huma...

SVMs suffer from the problem of large memory requirement and CPU time when trained in batch mode on large data sets. We overcome these limitations, and at the same time make SVMs suitable for learning with data streams, by constructing incremental learning algorithms. We first introduce and compare different incremental learning techniques, and show that they are capable of producing performanc...

This paper mainly deals with a two phase service queueing model with gated service vacation. In this gated service vacation model, only those customers who are present in the queue when the server starts a batch mode service are taken into the batch. We have derived probability generating functions of the system size and the orbit size. We have investigated the conditions under which the steady...

The multi®essel batch distillation column, as well as con®entional batch distillation, ( ) can be operated in a closed total reflux mode where the products are collected in ®essels along the column. A pre®iously proposed and simulated feedback control strategy for the closed operation is to indirectly adjust the ®essel holdups by using the reflux flow out of the ®essel to control the termperatu...

We propose a computer-aided methodology to automatically generate production schemes for chemical batch plants operating in multi-batch mode. Our approach is based on the following principles: (1) the plant is modeled at the level of process operations whose behavior is specified by timed automata, (2) the production schemes are generated using algorithms for reachability analysis of timed auto...

Multivessel batch distillation is a promising alternative to conventional batch distillation. Earlier studies proved the feasibility of temperature control in a closed operation mode, that is, when no product is removed until the end of the process. In this article, the influence of the reflux strategy during the initial start-up period is investigated in detail. This is a very important task i...

Jute modified has been used for adsorption of Cr (VI), Cd (II) and Pb (II) ions over a range ofinitial metal ion concentration. Adsorption process is done in batch mode. Adsorption isotherms ofthe heavy metals on adsorbents prepared were determined and correlated with common isothermequations. It was found that the Freundlich isotherm is better than Langmuir for explaining thebehavior of adsorp...