We examine the evolution of the Tully–Fisher relation (TFR) using a sample of 89 field spirals for which we have measured confident rotation velocities (V rot). This sample covers the redshift range 0.1 z 1, with a median of z = 0.33. The best-fitting TFR has a slope consistent with that measured locally, and we find no significant evidence for a change with redshift, although our sample is not...

We evaluated the quantitative value of a simple model of erythropoiesis, based on the basic assumptions that the red blood cell (RBC) mass determines erythropoietin (Epo) production, which in turn stimulates erythropoietic activity. The RBC mass was quantitated by direct isotopic measurement (RCM), Epo production by serum Epo levels, and erythropoiesis by the ferrokinetic measurement of the ery...

Temperature field reconstruction of heat source systems (TFR-HSS) with limited monitoring sensors occurred in thermal management plays an important role real time health detection system electronic equipment engineering. However, prior methods common interpolations usually cannot provide accurate performance as required. In addition, there exists no public dataset for widely research to further...

The prospective French cessation trial, Stop Imatinib trial (STIM) represents a breakthrough in Treatment-Free Remission (TFR) research in Chronic Myeloid Leukemia (CML) treatment with Tyrosine Kinase Inhibitors (TKIs). About 40% had long-term complete molecular response (CMR) after imatinib cessation in STIM trial. It demonstrated that imatinib cessation might be possible in monotherapy if CMR...

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed CIS (<120 days) for disturbances in the p...

Cell-surface receptors that undergo clathrin-mediated endocytosis contain short amino acid sequences in their cytoplasmic domain that serve as internalization signals. Interactions between these sequences and components of the endocytic machinery should become limiting upon overexpression of the constitutively recycling transferrin receptor (TfR). A tetracycline-responsive system was used to in...

Two rat monoclonal antibodies to the murine transferrin receptor (TFR) were each conjugated to recombinant ricin toxin A chain (rRTA). The monoclonal antibodies, R17 217 and YE1/9.9, bound to partially overlapping antigenic determinants on the murine TFR that were distinct from the transferrin binding site. Immunotoxins R17 217-rRTA and YE1/9.9-rRTA were potent cytotoxins for mouse cell lines i...

The blood-brain barrier (BBB) is an obstacle for antibody passage into the brain, impeding the development of immunotherapy and antibody-based diagnostics for brain disorders. In the present study, we have developed a brain shuttle for active transport of antibodies across the BBB by receptor-mediated transcytosis. We have thus recombinantly fused two single-chain variable fragments (scFv) of t...

Indigenous populations living in villages in Brazil have presented high total fertility rates (TFR) that have increased over time in some cases. Meanwhile, data from the Brazilian Institute of Geography and Statistics (IBGE) or National Census Bureau show a decline in the TFR for the total self-declared indigenous population (combining urban, rural, and specific rural residence). The current st...

The recycling itinerary of plasma membrane transferrin receptors (TFR) was charted in IgG-secreting mouse myeloma cells (RPC 5.4) by tagging surface receptors with either bound anti-transferrin receptor antibodies (anti-TFR) or Fab fragments thereof and determining the intracellular destinations of the tagged receptors by immunocytochemistry. By immunofluorescence, TFR tagged with either probe ...