BACKGROUND Human papillomavirus (HPV) is recognized as the key risk factor for a distinct subset of oropharyngeal squamous cell carcinoma. P16 is a reliable, sensitive surrogate marker for HPV and confers a positive prognostic advantage. Basaloid differentiation on hematoxylin and eosin (H&E) staining is anecdotally noted by some pathologists to be associated with p16 positivity. This associati...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Im ag es Basaloid squamous cell carcinoma (BSCC), an uncommon tumor with a predilection for the upper aerodigestive tract, is considered a distinct variant of squamous carcinoma due to its unique histological features and aggressive clinical behavior [1,2]. To the best of our knowledge, BSCC with a primary origin in the skin is extremely rare, although metastatic deposits of this type of cancer...

Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity. The conventional tumour and several histologic subtypes of SCC present morphologic features and specific behaviour when they occur in the oral mucosa. For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biolo...

Introduction Parotid gland squamous cell carcinoma is an uncommon aggressive neoplasm with poor prognosis. Aural polyps are usually the presenting features of chronic suppurative otitis media, tuberculous otitis media, and adenoma or carcinoma. The malignant aural polyp is very rare. Parotid gland carcinoma masquerading as an aural polyp has rarely been described in the literature. ...

      Abstract: development of squamous cell carcinoma from sebaceous cyst is uncommon.in this report , we report a77- old female patient who has had a sebaceous cyst for 20 years. The cyst started to grow during the last year. The patient underwent an operation for excision biopsy and The diagnosis was squamous cell carcinoma.

OBJECTIVES To document the clinical and histopathological characteristics of basaloid squamous cell carcinoma (BSCC). To add five new cases to the literature and compare them with another published series. CASES retrospective review of five cases with the diagnosis of BSCC of the larynx. RESULTS all the patients were male. They were heavy smokers and drinkers. Most of the tumours were supra...