BACKGROUND The Hamilton Depression Rating Scale (HDRS) is widely used to measure the severity of depression in mood disorders. Total HDRS score correlates with brain metabolism as measured by fludeoxyglucose F 18 ([(18)F]-FDG) positron emission tomography. The HDRS comprises distinct symptom clusters that may be associated with different patterns of regional brain glucose metabolism. OBJECTIV...

Simultaneous administration of alpha-ketoglutarate and ornithine, in a 1:2 molar ratio, may improve the effectiveness of ornithine as an arginine precursor in neonatal piglets by shifting ornithine metabolism away from oxidation and toward the synthesis of arginine and other metabolically important compounds. To study this proposed mechanism, enterally fed piglets were allocated to receive 1 of...

The properties of the basal Ca2+ influx (measured using cells labelled with 45Ca2+) in intact human red blood cells (RBC) were compared with those of 45Ca2+ influx induced by vanadate. The basal Ca2+ influx was not sensitive to inhibitors of vanadate-induced Ca2+ influx such as the HS-reagent p-chloromercuribenzoate and low concentrations of Cu2+, and also the sensitivity to nifedipine was sign...

Repeated observations within recent years have shown that the oral administration of iodine will usually be followed by a striking reduction in the basal metabolism in patients with exophthalmic goiter. A histologic study of the thyroid glands which have been removed from these patients gives evidence that definite involutional changes follow the use of iodine which indicate an anatomic regress...

Polychlorinated biphenyls (PCBs) are environmental pollutants associated with non-alcoholic-steatohepatitis (NASH), diabetes, and obesity. We previously demonstrated that the PCB mixture, Aroclor 1260, induced steatohepatitis and activated nuclear receptors in a diet-induced obesity mouse model. This study aims to evaluate PCB interactions with the pregnane-xenobiotic receptor (Pxr: Nr1i2) and ...