BACKGROUND Patients with major depressive disorder (MDD) accompanied by physical symptoms may be less responsive to antidepressant treatment. Quetiapine has been evaluated in the treatment of bipolar depression and has been recently approved as an add-on therapy for unipolar depression. Less is known about the efficacy of combination therapies in patients suffering from MDD with somatic symptom...

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevated cortisol (CORT) levels are characteristics of the pathophysiology of major depressive disorder. The aim of this study was to determine whether increased plasma CORT levels appear in patients with major depression and if effective antidepressant treatment by clomipramine (CLO) leads to regulation of CORT level. Plasma CO...

INTRODUCTION New evidence suggests that the efficacy of antidepressants occurs within the first weeks of treatment and this early response predicts the later response. The purpose of the present study was to investigate if the partial response in the first week predicts the response at the end of treatment in patients with major depressive disorder who are treated with either antidepressant med...

OBJECTIVE(S) Folic acid, a micronutrient supporting the natural defense system, may elevate antidepressant responses, although the lymphocyte serotonergic system has not been explored in folate-supplemented depressed patients. METHODS Twenty-seven patients were randomly assigned to groups receiving fluoxetine (20 mg) and folic acid (10 mg/day) or fluoxetine and placebo for 6 weeks. Clinical o...

Abstract Hydroxyapatite (HAp) with good mechanical properties is a promising material meant for number of useful bids in dentistry and orthopedic biomedical engineering applications drug delivery, bone defect fillers, cements, etc. In this paper, comprehensive review has been done, by reviewing different literatures related to synthesis techniques, property testing, method calcination character...

Background: Adolescence is an important period in human life and the low-level access of adolescents to reproductive and sexual health services is a concern because preventive, diagnostic and therapeutic services are needed for healthy sexual and reproductive behaviors. This study was conducted with the aim of considering the barriers against adolescent access to repro...

spreading faba bean (vicia faba) cultivation can enhance the sustainability of cropping systems and have other important benefits. however, there is little information on the various aspects of production management for this crop. then, this experiment was carried out to study the response of some agronomic characteristics of faba bean cv barakat to inter- (15, 30, 45 and 60 cm) and intra-row (...

The problem of motion planning and control of mobile robots has attracted the interest of researchers in view of its theoretical challenges because of their obvious relevance in applications. From a control viewpoint, the peculiar nature of nonholonomic kinematics and dynamic complexity of the mobile robot makes that feedback stabilization at a given posture cannot be achieved via smooth time-i...