The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against Borrelia burgdorferi in suspension (in vitro) and in cell line cultures (in vivo). In the suspension method, 0.01% octenidine at 20°C and 35°C was bactericidal to Borrelia afzeli; Borrelia garini, B. burgdorferi sensu stricto after 5 minutes treatment. Increase of the tempe...

Ala’Aldeen, D. A. et al. (2000) “Dynamics of meningococcal long term carriage among university students and their implications for mass vaccination” J Clin Microbiol 38(6):2311-2316. Andrews, N et al. (2003) “Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England” Clin Diagn Lab Immunol 10(5)...

It has been suggested that the microbicidal effect of metronidazole is mediated by an intermediate in nitro group reduction. We have found that the addition of Escherichia coli enhances the lethal effect of metronidazole on Bacillus fragilis and suggest that this intermediate may form in one bacteria and kill another. Because acetamide forms during the reduction of metronidazole, we examined th...

Two in vitro tests, the serum killing level and the serum bactericidal rate assays, were evaluated for correlation with therapeutic efficacy in the rabbit model of Staphylococcus aureus endocarditis. Animals were treated with nafcillin alone and in combination with tobramycin or gentamicin. Both were effective therapies, but rapidity of vegetation sterilization by the single and combined regime...