نتایج جستجو برای: bach2
تعداد نتایج: 191 فیلتر نتایج به سال:
Abstract Introduction: Genome- and transcriptome-wide analyses continue to enhance our understanding of the molecular pathogenesis cancer. In lymphomas, this has enabled identification hundreds recurrently mutated genes, highlighting genetic heterogeneity relationships both within among clinical entities. While growing availability lymphoma genomic data sets can be leveraged integrate into diag...
Small cell lung cancer (SCLC) accounts for 14% of diagnoses and is characterized by rapid onset chemoresistance poor clinical outcomes. SCLC has four major subtypes driven transcription factors ASCL1, NEUROD1, POU2F3, YAP1. Recent studies have also shown intratumoral heterogeneity with respect to ASCL1/NEUROD1 balance MYC amplification – which are potential mechanisms underlying SCLC’s aggressi...
Toxicity induced by radiation therapy is a curse for cancer patients undergoing treatment. It is imperative to understand and define an ideal condition where the positive effects notably outweigh the negative. We used a microarray meta-analysis approach to measure global gene-expression before and after radiation exposure. Bioinformatic tools were used for pathways, network, gene ontology and t...
OBJECTIVE The incorporation of rituximab in immunochemotherapy has improved treatment outcomes for diffuse large B-cell lymphoma, but the prognosis for some diffuse large B-cell lymphomas remains dismal. Identification of adverse prognostic subgroups is essential for the choice of appropriate therapeutic strategy. METHODS We retrospectively investigated the impact of so-called 'double-hit' cy...
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