1. In order to discover whether the changes in reactivity are related to the primary cause of hypertension in spontaneously hypertensive rats (SHR) or are just an adaptation induced by the high arterial blood pressure we tested the contractile response of a visceral smooth muscle from such rats. 2. Longitudinal strips of the fundus from 20 week old male and female SHR and Wistar normotensive (...

Mn2+ and to some degree Fe2+, but not Mg+, Ca2+, ba2+, Sr2+, Co2+, Ni2+, La3+, or Fe3+ were able to serve as effective metal cofactors for sea urchin sperm guanylate cyclase. The apparent Michaelis constant for Mn2+ in the presence of 0.25 mM MnGTP was 0.23 mM. In the presence of a fixed free mn2+ concentration, variation in mngTP resulted in sigmoid velocity-substrate plots and in reciprocal p...

PURPOSE To identify and partially characterize the ionic currents contributing to the whole-cell conductance of cultured human corneal epithelial cells. METHODS Epithelial cells were scraped from human donor corneas and cultured for use in patch-clamp experiments. Amphotericin B and the perforated-patch configuration were used to measure whole-cell currents in cells isolated from confluent mo...

BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine] produced a concentration-dependent membrane hyperpolarization of cultured human bladder myocytes, assessed as either a reduction in fluorescence of the voltage-sensitive dye bis-(1,2-dibutylbarbituric acid)trimethine oxonol (EC50 = 1.26 +/- 0.6 microM) or by direct electrophysiological measurement (EC50 = 1.49 +/...

1. The nature, distribution and function of rectifying channels in rat spinal root myelinated axons has been assessed with selective blocking agents and a variety of intracellular and extracellular recording techniques. 2. The electrotonic responses of roots poisoned with tetrodotoxin (TTX) to constant current pulses had fast (rise time much less than 1 ms) and slow components, which were inter...

3 4 Cassie Wilson, Mark A. King and Maurice R. Yeadon 5 6 1 Department for Health, University of Bath, Bath, BA2 7AY, UK. 7 2 School of Sport, Exercise and Health Sciences, Loughborough University, 8 Loughborough LE11 3TU, UK. 9 10 11 12

Observations of lunar tides in the mesosphere and lower thermosphere at Arctic and middle latitudes D. J. Sandford, H. G. Muller, and N. J. Mitchell Centre for Space, Atmospheric & Oceanic Science, Department of Electronic and Electrical Engineering, University of Bath, Bath, BA2 7AY, UK Received: 21 February 2006 – Accepted: 20 March 2006 – Published: 12 June 2006 Correspondence to: D. J. Sand...

a Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. b Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. c Department of Pharmacology, University of Oxford, Mansfield Ro...

Heterofunctionalization catalysis with organometallic complexes of calcium, strontium and barium BY ANTHONY G. M. BARRETT1, MARK R. CRIMMIN2,*, MICHAEL S. HILL2 AND PANAYIOTIS A. PROCOPIOU3 1Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK 2Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK 3GlaxoSmithKline Medici...

Hedlund [He] constructed Riemannian metrics on n-tori, n ≥ 3 for which minimal geodesics are very rare. In this paper we construct similar examples for every nilpotent fundamental group. These examples show that Bangert’s existence results of minimal geodesics [Ba2] are optimal for nilpotent fundamental groups.