Abstract Study question Is it possible to predict clinical pregnancy using Machine Learning models on day 6 after embryo transfer an acceptable degree of certainty? Summary answer Using selected biochemical markers is build a machine learning model pregnancy. What known already Human chorionic gonadotropin (β-hCG) considered the main early predictor Due fact that highest percentage spontaneous ...

Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces endogenous leptin expression. We also found that hCG increased cAMP intracellular levels in BeWo cells in a dose-depe...

Successful embryo development requires an extensive endometrial angiogenesis in proximity of implantation site. The glycoprotein hCG is produced even before implantation by trophoblast in normal pregnancy. In this manuscript, we demonstrate an angiogenic effect of hCG in several in vivo (chick chorioallantoïc membrane, matrigel plug assay, aortic ring assay) and in vitro experimental models. In...

HCG is composed of two subunits, HCGalpha and HCGbeta. During early pregnancy, HCG stimulates progesterone production in the corpus luteum, and injection of HCG is widely used to induce ovulation in assisted reproduction treatment (ART). Under experimental conditions, the free subunits have been shown to exert functions other than those of HCG, but the relevance of these remains to be determine...

Background: Amenorrhea and extraplacental production of serum human chorionic gonadotropin (hCG), particularly in young women, can mimic a pregnancy unknown location. Elevated hCG the absence pose diagnostic dilemma has led to potentially harmful unwarranted interventions including chemotherapeutic agents like methotrexate or have delay necessary medical women. We report case demonstrate that a...

A theoretical study of differences in broadband high-index-contrast grating (HCG) reflectors for TM and TE polarizations is presented, covering various grating parameters and properties of HCGs. It is shown that the HCG reflectors for TM polarization (TM HCG reflectors) have much thicker grating thicknesses and smaller grating periods than the TE HCG reflectors. This difference is found to orig...

OBJECTIVE To examine the properties of the unique degraded forms of hCG produced in familial hCG syndrome and to describe 15 cases referred to the USA hCG Reference Service. STUDY DESIGN Total hCG was detected by Immulite total hCG assay. The molecules missing the beta-subunit C-terminal peptide were detected by the Centaur total hCG assay; the proportion of molecules missing the beta-subunit...

Human chorionic gonadotrophin (hCG) is released from placental trophoblasts and is involved in establishing pregnancy by maintaining progesterone secretion from the corpus luteum. Serum hCG is detected in the maternal circulation within the first 2-3 wks of gestation and peaks at the end of the first trimester before declining. In Down's syndrome (DS) pregnancies, serum hCG remains significantl...

Endometrial cancer (EC) is a hormone-dependent cancer that currently represents the most frequent malignancy of the female reproductive tract. The involvement of steroid hormones in EC etiology and progression has been reported. More recently, gonadotropins, and, in particular LH/hCG, are emerging as novel regulators of tumor progression. In the present review, we discuss the role of the LH/hCG...

Introduction/Objective. Fetal growth restriction (FGR) is associated with increased fetal and neonatal mortality morbidity. The study objective was to investigate the correlation of maternal blood biochemical markers routinely determined in first second trimester screening ultrasound surveillance parameters prediction condition singleton pregnancies. Methods. In we measured serum levels beta su...