Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A. ustus among hematopoietic stem cell transplant (HSCT) recipients. Six patients with infections were identified; 3 infections each occurred in both 2001 and 2003. Molecular typing by using randomly amplified polymorphic DNA (RAPD) and ...

Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesi...

Fungal infections cause significant morbidity and mortality in immunocompromised patients. Oral candidosis is the most common opportunistic infection in human patients infected with HIV and AIDS. , 2 Paralleling the increased prevalence of fungal infections has been the introduction of new antifungal agents and the recognition of resistance. The chronic use of azoles for prophylaxis in systemic...

Some nitrogen-containing heterocycles can form both anionic (with abstraction of the N -H proton) and cationic derivatives (with addition of the proton to the pyridinic nitrogen atom). These include, in par­ ticular, 3,5-dichloro-l,2,4-triazole and 4,5-dichloro-2methylimidazole. These compounds were studied by 35C1 NQR spectroscopy [1,2]. Quantum-chemical analyses of the electronic structure of...

picalis that was resistant to fluconazole, itraconazole, and clotrimazole. Because he had a history of injection drug use, it is possible that he may have been colonized by this strain of Candida for some time and acquired the fungemia from injecting. Although he was not HIV-positive, he may have shared needles or been exposed to someone who was HIV-positive and thus may have become colonized w...

Background Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms. Method The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined. The changes in the g...

Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...