PURPOSE Tumor response to neoadjuvant chemotherapy (NAC) may adversely affect the identification and accuracy rate of sentinel lymph node biopsy (SLNB). This study was conducted to evaluate the feasibility of SLNB in node-positive breast cancer patients with negative axillary conversion after NAC. MATERIALS AND METHODS Ninety-six patients with positive nodes at presentation were prospectively...

Introduction: One of the major problems of lymphoscintigraphy is the time of patient presence in the nuclear medicine wards. The operating room schedule can be compromised if the patients stay longer than usual in the nuclear medicine departments. However, too early imaging can be falsely negative for sentinel node visualization and delayed imaging may be required. The aim of t...

BACKGROUND The current management of the axilla in level 1 node-positive breast cancer patients is axillary lymph node dissection regardless of the status of the level 2 axillary lymph nodes. The goal of this study was to develop a nomogram predicting the probability of level 2 axillary lymph node metastasis (L-2-ALNM) in patients with level 1 axillary node-positive breast cancer. MATERIALS A...

Introduction. Patients with a positive sentinel lymph node biopsy may undergo delayed completion axillary dissection. Where intraoperative analysis is available, immediate completion axillary dissection can be performed. Alternatively, patients may undergo primary axillary dissection for breast cancer, historically or when preoperative assessment suggests axillary metastases. This study aims to...

the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...

Correspondence to: Charalampos Seretis, MBBS, MSc. Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Pensnett Road, DY1 2HQ, Dudley, West Midlands, United Kingdom. Tel: +44 1384 456111, Fax: +44 1384244051, E-mail: [email protected]. Received : 26/06/2016; Accepted : 04/07/2016 The advent of sentinel lymph node biopsy (SLNB), in conjunction with tissue-sparing surgery and...

BACKGROUND Recently, the American College of Surgeons Oncology Group Z0011 trial demonstrated that axillary lymph node dissection (ALND) could be safely avoided in selected breast cancer patients with limited nodal disease and having breast conservation therapy. However, for node positive (N+) mastectomy patients, full ALND remains the standard of care. Hypothesizing that omission of complete A...

PURPOSE During a sentinel lymph node biopsy (SLNB) for breast cancer, the appropriate number of sentinel lymph nodes (SLNs) to be removed for accurate axillary staging is still controversial. We hypothesized that there might be an optimal threshold number of SLNs. We investigated how many SLNs should be removed to achieve an acceptable accuracy and ensure minimal morbidity. METHODS We reviewe...

A forty-six-year-old female presented with a history of left axillary pain, discomfort, chronic fatigue and palpitations. Clinical examination revealed large, tender nodules in the left axilla which were thought to represent enlarged axillary lymph nodes. Multiple dilated veins were visible in the left axillary region. The patient was diagnosed with Mondor’s disease based on the typical mammogr...

INTRODUCTION Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare. CASE REPORT The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck diss...