Purpose To investigate the biocompatibility of an injectable hydrogel and its ability to control myopia progression in guinea pigs. Methods The study used a hydrogel synthesized from acrylated hyaluronic acid with a conjugated cell-binding peptide and enzymatically degradable crosslinker. Seven-day-old guinea pigs were first form deprived (FD) with diffusers for 1 week. One group was kept as ...

IT IS generally agreed that simple myopia and degenerative myopia are separate conditions, the former being a normal chance variant in the biological series which includes emmetropia and hypermetropia (Duke-Elder, 1949) and the latter a pathological condition. Degenerative myopia in its advanced stage consists of an association of defects: a highly myopic refraction, chorio-retinal degeneration...

Axial length of the eye correlates with magnitude myopia. However, there are conflicting reports on relationship between certain corneal parameters myopia magnitude. The objective this study was to compare ocular biometry and emmetropic myopic groups. Participants (n=127) were categorized as emmetropia (spherical equivalent, SE, ±0.50D), low (-0.75D≤SE<-6.00D) high (SE≥-6.00D). difference in...

PURPOSE To describe longitudinal changes in corneal curvature (CC) and axial length (AL) over 14 years, and to explore the relationship between AL and CC, and the axial length/corneal radius (AL/CR) ratio. METHODS In total 469, 6 to <12-year-old, children were enrolled in COMET. Measurements of refractive error, CC (D), CR (mm), and ocular component dimensions including AL were gathered annua...

BACKGROUND The purpose of this study was to examine the choroidal thickness of patients with high myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare them with healthy subjects. METHODS We first conducted a cross-sectional study and then performed a meta-analysis to address this issue further. Using enhanced depth imaging optical coherence tomography (EDI-OC...

PURPOSE To learn whether gamma-aminobutyric acid (GABA) participates in retinal mechanisms that influence refractive development. METHODS White leghorn chicks, some of which wore a unilateral goggle to induce myopia, received daily intravitreal injections of agonists or antagonists to the major GABA receptor subtypes. Eyes were studied with refractometry, ultrasound, and calipers. Retinas of ...

PURPOSE To investigate the impact of a positive family history of high myopia on the level and onset of myopia and its ocular components. METHODS A cross-sectional study was conducted. The participants (aged 17 to 45 years) were categorized into four groups: normal, mild, moderate, and high myopia. The age of first glasses for myopia was used as the onset of myopia. The impact of the family h...

PURPOSE To examine the influences of ethnicity, parental myopia, and near work on spherical equivalent refraction (SER) and axial length (AL) in a population-based sample of 12-year-old Australian children. METHODS Year-7 children in the Sydney Myopia Study (n = 2353, 75.3% response) underwent an ophthalmic examination including cycloplegic autorefraction (1% cyclopentolate) and ocular biomet...