Growth factors and their receptor play a major part in normal growth and differentiation and also in tumour development and progression. Mutations or overexpression of growth factor receptors is associated with aggressive cancers and poor prognosis for patients. Growth factor receptors are transmembrane tyrosine kinase proteins that transduce growth factor signals imparted by their binding to s...

G et ready! The landscape in medicine is probably going to change rapidly. The starting bell rang in December 2010 in Washington, DC, with very little fanfare when the Food and Drug Administration (FDA) banned doctors from prescribing Avastin to patients with advanced-stage breast cancer. 1 Avastin, a potent but costly drug, has worked in some clinical trials by halting the spread of cancer and...

Age-related macular degeneration (AMD) is the leading cause of visual loss in the developed World in patients over age 55. Therapeutic advances in the dry (non-exudative) form of AMD have been very modest with a protective role demonstrated for supplemental anti-oxidant vitamin therapy in patients showing high risk characteristics for future progression. In contrast, a major advance in the trea...

CASE REPORT We report a case of a 30-year-old male with acquired vitelliform detachment (AVD) secondary to cuticular drusen and suffering from metamorphopsia in his right eye. Intravitreal bevacizumab (Avastin) was administered, achieving successful results. DISCUSSION An independent disease, of unknown genetic phenotype, caused by a generalized dysfunction of the retinal pigment epithelium (...

purpose: to study the effects of adding intravitreal bevacizumab (avastin) to conventional laser treatment on regression of retinal neovascularization in threshold rop. methods: intravitreal injection of bevacizumab (1.25 mg) in one eye of each of three newborns with threshold rop was performed in addition to laser treatment. the other eye of each patient was treated with laser alone. changes i...

purpose: to report subconjunctival injection of bevacizumab (avastin) for treatment of primary active pterygium. method: patients with primary active pterygia without other ocular disease, pregnancy or diabetes mellitus were enrolled. patients were randomly allocated into two groups to receive injection of avastin or placebo. patients were evaluated for changes in photophobia, conjunctival cong...