The privileged position of the fetus, containing foreign protein that is not rejected by its mother, has intrigued biologists for many years. More recently, it has been realised that certain maternal autoimmune diseases, particularly immune thrombocytopenia, Graves' disease, pemphigoid gestationis (herpes gestationis), myasthenia gravis, and systemic lupus erythematosus may affect the fetus by ...

autoimmune lymphoproliferative syndrome (alps) is an uncommon nonmalignant lymphoproliferative disease which is characterized by chronic, persistent or recurrent lymphadenopathy, splenomegaly, hepatomegaly, immune cytopenia, hypergammaglobinemia and increased risk of lymphoma. we report a 2-year old boy with hepatosplenomegaly as first presentation. petechial and purpuric rashes with massive ce...

Seventy-nine patients with chronic lymphocytic leukaemia were evaluated for the presence of autoimmune diseases and autoantibodies. One patient has polymyositis and two additional patients presented with features suggestive of pernicious anaemia and chronic active hepatitis. The Coombs' direct test was positive in 7% and immune thrombocytopenia was present in 8.1% of patients. Five (7%) patient...

The natural history of the immune thrombocytopenia (ITP) is interesting and intriguing because it traces different steps underlying autoimmune diseases. The review points out the main steps that have accompanied the stages of its history and the consequential changes related to its terminology. ITP is an autoimmune disease resulting from platelet antibody-mediated destruction and impaired megak...

The privileged position of the fetus, containing foreign protein that is not rejected by its mother, has intrigued biologists for many years. More recently, it has been realised that certain maternal autoimmune diseases, particularly immune thrombocytopenia, Graves' disease, pemphigoid gestationis (herpes gestationis), myasthenia gravis, and systemic lupus erythematosus may affect the fetus by ...

Objectives: We have demonstrated that allogeneic bone marrow transplant (BMT) with low-dose total body irradiation (TBI) and anti-CD40L mAb without lymphoablative treatment achieved durable mixed chimerism and permanent donor-specific tolerance. Also, allogeneic mixed chimerism induced by anti-CD40L-containing regimen overcomes both alloand autoimmunity in NOD mice. BXSB mice with a lymphoproli...

Thrombocytopenia in cirrhotic patients is usually attributed to splenic pooling whereas in idiopathic thrombocytopenic purpura it is related to platelet bound immunoglobulin (PA-IgG). Since primary biliary cirrhosis (PBC) is an autoimmune disorder we have undertaken a prospective study to assess the frequency and possible relationship of PA-IgG to thrombocytopenia in this condition. Sixty-two p...

To the Editor I read with great interest the article " A case of isoniazid-induced thrombocytopenia: recovery with im-munoglobulin therapy " in volume 51, number 7, April 2012 issue of your journal (1). As the authors mentioned, this case represents a rare adverse event associated with isoni-azid therapy, namely, isoniazid-induced thrombocytopenia. It is well known that almost all anti-tubercul...