multiple sclerosis (ms) is an autoimmune inflammatory demyelinating disease of the central nervous system. the aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (ucb-msc) derived neural progenitor cell (mdnpc) in eae, an experimental model of ms. to initiate neuronal differentiation of ucb-mscs, the pre-inductio...

background autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. most of the cases are associated with viral or bacterial infections. in some cases, aiha can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. case report especially in children younger than 2 y...

background: ataxia telangiectasia (at) is one of the combined immunodeficiency syndromes with immunologic, neurologic, endocrinologic, hepatic and cutaneous abnormalities. regarding the fact that autoimmune disorders; such as autoimmune hemolytic anemia (aiha), are not generally expected in the course of at, we present a patient with an unusual presentation of these two conditions. case present...

CONTEXT We report a rare case of autoimmune neutropenia associated with autoimmune pancreatitis. CASE REPORT A 61-year-old man was referred to our hospital with slight epigastralgia. He had been admitted to another hospital with exacerbation of diabetes and jaundice. Blood tests showed low white blood cell and neutrophil counts (1,800 µL-1 and 3%, respectively), and elevated transaminase, bil...

BACKGROUND The occurrence in the same patient of three or more autoimmune diseases defines multiple autoimmune syndrome (MAS). Various autoimmune dermatoses, especially pemphigus, have been described in association with systemic autoimmune diseases as component of MAS. AIM The aim of our study is to describe MAS with a new combination in a 55-year-old woman having a pemphigus vulgaris, associ...

Addison’s disease or autoimmune adrenalitis: These are autoimmune conditions, constituting 80% of all cases. Autoimmune adrenalitis may be part of Type 2 autoimmune polyglandular syndrome, which can include type 1 diabetes, hyperthyroidism, and autoimmune thyroid disease (also known as Hashimoto’s thyroiditis), and Hashimoto’s disease. Hypogonadism may also present with this syndrome. Other dis...

common variable immunodeficiency (cvid) is a heterogeneous group of disorders characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura (itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders which may be seen in association with cvid. among 85 cvid patients, seve...

background: celiac disease (cd) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (lft). as there is no precise data from our country in this regard, we investigated the prevalence of cd in patients presenting with abnormal lft. methods: from 2003 to 2008, we measured iga anti-tissue transglutaminase (t-tg) antibody (with elisa technique) with...

background: experimental autoimmune encephalomyelitis (eae) is an animal model of multiple sclerosis, which is a demyelinating and an inflammatory disease of central nervous system. recent studies have established that some molecules such as lipocaline2 (lcn2), which expresses during inflammatory conditions, play an important role in eae pathogenesis and might involve in its treatment process. r...

background: multiple sclerosis (ms) is known as a progressive central nervous system inflammatory disease. certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in ms etiology. because of the important role of oxidative stress, antioxidant therapy for ms has received more attention. although coenzyme q10 (coq10) acts as an antioxidant, there is ...