BACKGROUND Bacille Calmette-Guérin (BCG) vaccine is given to Canadian Aboriginal neonates in selected communities. Severe reactions and deaths associated with BCG have been reported among infants born with immunodeficiency syndromes. The main objective of this study was to estimate threshold values for severe combined immunodeficiency (SCID) incidence, above which BCG is associated with greater...

OBJECTIVE The authors' goal was to assess the validity of DSM-IV diagnoses obtained with the Spanish versions of the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) and the Structured Clinical Interview for DSM-IV (SCID) compared with the longitudinal, expert, all data (LEAD) procedure in a group of substance abusers. METHOD A total of 105 substance abusers recruited...

A small animal model that could be infected with human immunodeficiency virus 1 (HIV-1) after peripheral inoculation would greatly facilitate the study of the pathophysiology of acute HIV-1 infection. The utility of SCID mice implanted with human fetal thymus and liver (SCID-hu mice) for studying peripheral HIV-1 infection in vivo has been hampered by the requirement for direct intraimplant inj...

هدف: پژوهش حاضر با هدف بررسی مقایسه اثربخشی گروه درمانی شناختی – رفتاری و ذهن ­آگاهی مبتنی بر شناخت کاهش رفتارهای پرخطر در معتادان ترک افیونی صورت گرفت. روش: روش این شبه آزمایشی طرح پیش آزمون پس همراه کنترل است. جامعه­ی آماری شامل کلیه افراد وابسته به مواد مراجعه کننده مرکز اعتیاد شبکه بهداشت درمان شهرستان سرپل ذهاب نیمه اول سال 1396 بود، نمونه­ گیری دسترس تعداد 36 نفر تشخیص وابستگی اساس معیاره...

In this study we aimed to determine the association between bilateral calcaneal fractures and suicide attempt some socio-demographic characteristics. This was conducted among patients admitted emergency departments of four trauma centers with January 2014 March 2017. The Sociodemographic Data Form, Structured Clinical Interview for Diagnostic Statistical Manual Mental Disorders fourth edition (...

DNA damage is part and parcel of the life a cell an organism. Cells respond to by initiating response (DDR) pathways that allow for removal damaged subsequent repair. At least five major repair operate in humans – base excision (BER), nucleotide (NER), mismatch (MMR) double-strand break (DSB), which involves homologous recombination (HR) non-homologous end-joining (NHEJ). This talk will focus o...

V(D)J recombination, accountable for the diversity of T cell receptor- and immunoglobulin-encoding genes, is initiated by a lymphoid-specific DNA double-strand break. The general DNA repair machinery is responsible for the resolution of this break. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku70, Ku80, DNA-PKcs, XRCC4 and DNA ligase IV) leads to a...

BACKGROUND Severe Combined Immune Deficient (SCID)/Urokinase-type Plasminogen Activator (uPA) mice undergo liver failure and are useful hosts for the propagation of transplanted human hepatocytes (HH) which must compete with recipient-derived hepatocytes for replacement of the diseased liver parenchyma. While partial replacement by HH has proven useful for studies with Hepatitis C virus, comple...

We addressed the question of whether cancers arising in an abnormally radiation sensitive normal tissue are also abnormally sensitive to ionizing irradiation. Germ line mutation-carrying mice with an enhanced radiation sensitivity of the normal tissue, the severe combined immunodeficient (SCID), and normally radiation sensitive mice (C3H) were used to study the sensitivity of normal and tumor t...