The purpose of this report is to describe a case of Cogan’s syndrome (CS) with atypical ophthalmic features, such as diffuse anterior scleritis and bilateral peripheral ulcerative keratitis. The article also discusses the clinical aspects, treatment and prognosis of this rare disease. A 66-year-old woman presented with bilateral a symmetric diffuse anterior scleritis and peripheral ulcerative k...

Atypical hemolytic syndrome is an extremely rare, life threatening, progressive disease. Approximately one to two cases per million are seen annually in the US. It is known to be associated with variety of conditions including infections, drugs, autoimmune conditions, vaccination, malignancy, organ transplantation, pregnancy, and metabolic conditions. We hereby describe a case of atypical hemol...

Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement component C5. Eculizumab must be administered intravenously, and moreover some patients with paroxysmal nocturnal hemoglobinuria on eculizumab have s...

Abstract Suppose we are given a discrete-valued time series $$X $$ X of observed events and an equally long binary sequence $$Y Y that indicates whether something interest happened at particular point in time. We consider the problem mining serial episodes, sequential patterns allowing for ga...

BACKGROUND Acral benign melanocytic lesions in white populations, particularly in subjects with atypical mole syndrome, have been poorly characterized until recently. The advent of dermoscopy has enabled more specific diagnoses of these pigmented skin lesions. OBJECTIVE To evaluate the clinical and dermoscopic features of benign volar lesions in a group of white patients with atypical mole sy...

<p class="abstract">Gomm-Button disease (Sweet syndrome) typically presents with abrupt onset of tender skin lesions accompanied by fever and neutrophilia. Histopathology shows the presence dense neutrophilic infiltrates, oedema without vasculitis. One criteria for diagnosis sweets syndrome is absence However, recent reports suggest that vasculitis should not exclude diagnosis. We present...

BACKGROUND Metabolic syndrome is a leading cause of morbidity and mortality in patients with schizophrenia, with a prevalence rate double that of nonpsychiatric populations. Given the amount of evidence suggesting a link between atypical antipsychotic medications and metabolic syndrome, several agencies have recommended regular clinical monitoring of weight, symptoms of hyperglycemia, and gluco...

Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian syndrome comprising two main clinical subtypes: Richardson's syndrome (RS), characterized by prominent postural instability, supranuclear vertical gaze palsy and frontal dysfunction; and PSP-parkinsonism (PSP-P) which is characterized by an asymmetric onset, tremor and moderate initial therapeutic response to levodopa...

KEY CLINICAL MESSAGE A 24-year-old man with diarrhea found to have acute renal failure with microangiopathic hemolytic anemia (MAHA). A diagnosis of hemolytic uraemic syndrome (HUS) was made. He was initiated on plasma exchange and hemodialysis. On day 6, he was started on eculizumab. His renal functions progressively improved. His main complication during eculizumab therapy was hypertension-re...