The neural circuitry and pharmacology underlying transient signal formation at the bipolar-amacrine cell interface were studied. Synaptic currents were measured with whole cell patch clamp in retinal slices. Cell types were identified with Lucifer yellow staining. Activity was initiated with puffs of kainate of known time course and spatial spread delivered at bipolar dendrites. OFF bipolar cel...

Anetoderma is a rare cutaneous disorder characterized by a loss of normal elastic tissue that presents clinically as atrophic patches located mainly on the upper trunk. Recent studies suggest immunological mechanisms may play a role in this process. Furthermore, a secondary form of macular atrophy occurs in the course of infectious diseases (e.g. syphilis and tuberculosis) and autoimmune diseas...

INTRODUCTION Severe symptomatic aortic stenosis is associated with a poor prognosis, with most patients dying 2-3 years after diagnosis. We analysed the proportion of patients with severe aortic stenosis not referred for aortic valve replacement (AVR) in a UK-based population and the clinical factors contributing to this. METHODS Retrospective analysis of patients with echocardiographic evide...

PURPOSE To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC). MATERIALS AND METHODS This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual ...

We have developed an efficient stochastic AVA inversion technique that works directly in a fine-scale stratigraphic grid, and is conditioned by well data and multiple seismic angle stacks. We use a Bayesian framework and a linearized, weak contrast approximation of the Zoeppritz equation to construct a joint log-Gaussian posterior distribution for Pand S-wave impedances. We apply a Sequential G...

The increasing complexity of assessing aortic stenosis (AS) will perhaps haunt cardiologists in years to come. Did we over-complicate it, were we overly ambitious in trying to identify those who might benefit from intervention? These are questions that we will be held accountable for by the vast numbers of patients who now carry some form of this diagnosis, and we have reason to be concerned. T...

Reaumuria vermiculata is a xero-halophytic specie widely distributed in the south of Tunisia. In the current study, antioxidant, anti-inflammatory and anticancer activities of Reaumuria vermiculata shoot extracts as well as its phenolic compounds were investigated in different solvent extracts (hexane, dichloromethane, methanol and water). Results showed a strong antioxidant activity, using the...

PURPOSE To evaluate the long-term progression of myopic maculopathy and functional outcome after treatment of myopic choroidal neovascularization (CNV) with photodynamic therapy (PDT) and/or intravitreal ranibizumab (IVR). METHODS Retrospective study with a cross-sectional evaluation. Eyes were assigned to 4 groups (PDT, IVR, PDT + IVR, dry myopic maculopathy) and evaluated with best-correcte...

Least-squares reverse-time migration (LSRTM) provides image of reflectivity with high resolution and compensated amplitude, but the computational cost is extremely high. One way to improve efficiency is to encode all of shot gathers into one or several super-shot gathers with designed encoding functions so as to solve a smaller number of wave-equations at each iteration. Another way is to use d...

OBJECTIVE To evaluate the long-term effect of intravitreal triamcinolone acetonide (IVT) treatment combined with photodynamic therapy (PDT) vs PDT alone for neovascular age-related macular degeneration. METHODS Prospective randomized study. Eighty-four patients were enrolled to receive PDT (n = 41) or IVT treatment followed by PDT (n = 43) within approximately a 7- to 15-day interval. All pat...