OBJECTIVE To determine the effect of atorvastatin on rat heart failure after myocardial infarction and to investigate the underlying mechanism of atorvastatin-mediated myocardium protection. METHODS Thirty-eight rats were randomly divided into three groups: a heart failure model group (model group), a heart failure plus atorvastatin treatment group (atorvastatin group) and a sham-surgery grou...

Aim of this investigation was to study the in vivo and in vitro drug interaction of glimepride with atorvastatin and rosuvastatin. In vitro drug interaction of glimepride with atorvastatin and rosuvastatin was studied using human pooled liver microsomes and evaluated using high performance liquid chromatography. In vivo pharmacokinetic drug interaction of glimepride (6 mg/kg) in coadministratio...

The aim of study was to investigate the anti-proliferative and inflammatory effects atorvastatin, rosuvastatin, simvastatin in lung cancer. statins were investigated Vero, BEAS-2B, A549 cell lines. In addition expressions BAX, BCL-2, TNFα, IL-10, IL-6, protein levels IL-6 determined. Cell viability MDA also measured. While numbers groups with low doses found be approximately 1x106/mL, prolifera...

The use of statins may have unnatural effects. A 54-year-old woman was admitted to the hospital with an incidental finding of hypercalcemia (10.8 mg/dL). There was no disease other than hyperlipidemia, and the patient had been on a course of atorvastatin calcium 10 mg for 1.5 years. A workup investigation to diagnose the cause of hypercalcemia was completed. The investigation did not reveal any...

Statins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and used to prevent increased risk cardiovascular cerebrovascular diseases. Although some their effects well known, little is known about ability regulate other lipid-related proteins which control apoptotic mechanisms. The aim this study was explore whether statins can bind cell death-inducing DNA fragmen...

OBJECTIVE The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a mediator for inflammatory response in arteries. The present study investigated the relationship between atorvastatin and the 5-lipoxygenase pathway in an atherosclerotic rabbit model. METHODS Thirty male New Zealand White Rabbits were randomized into negative control, positive control and atorvastatin groups....

BACKGROUND Experimental animal data suggest that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) might reduce enhanced sympathetic activity, a hallmark of hypertensive patients. This hypothesis was tested for the first time in patients with primary hypertension. METHODS AND RESULTS Using a prospective, randomized, placebo-controlled, double-blind, cross-over des...

Three accurate, precise, sensitive and economical procedures for simultaneous estimation of Atorvastatin Calcium and Telmisartan in tablet dosage form have been developed. The methods employed were absorbance correction method (I), first order derivative spectroscopic method (II) and duel wavelength method (III). The first method employs wavelength 328 nm for direct estimation of Telmisartan wh...

Statins, which are revolutionized cholesterol-lowing agents, have been reported to have unfavorable effects on the liver. Inflammatory stress is a susceptibility factor for drug-induced liver injury. This study investigated whether inflammatory stress sensitized the liver to statin-induced toxicity in mice and explored the underlying mechanisms. We used casein injection in ApoE-/- mice to induc...

Osteosarcoma is the most common primary bone tumor in children and young adults. Resistance to chemotherapeutic drugs is a major problem that is responsible for the failure of treatment. This points to the need for increasing the responsiveness to cytotoxic drugs. We previously showed that lipophilic statins induce apoptosis in human osteosarcoma cells. In this study, we investigated the effect...