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Articles you may be interested in Adhesive-free colloidal probes for nanoscale force measurements: Production and characterization Rev. Improved in situ spring constant calibration for colloidal probe atomic force microscopy Rev. Accurate noncontact calibration of colloidal probe sensitivities in atomic force microscopy Rev. A calibration method for lateral forces for use with colloidal probe f...

Many researchers have studied the effects of changing the surface on fouling and cleaning. In biofouling the ‘Baier curve’ is a well-known result which relates adhesion to surface energy, and papers on the effect of changing surface energy to food fouling can be found more than 40 years ago. Recently the use of modified surfaces, at least at a research level, has been widespread. Here two diffe...

The combination of ultrasound with atomic force microscopy (AFM) opens the high lateral resolution of scanning probe techniques to ultrasonics. Atomic force acoustic microscopy (AFAM) and lateral atomic force acoustic microscopy are techniques which use the vibration modes of AFM cantilevers. In the AFAM-mode the cantilever is vibrating in one of its flexural resonances while the sensor tip is ...

The periodic impact force induced by the tip–sample contact in tapping mode atomic force microscopy (TM-AFM) gives rise to anharmonic oscillations of the sensing cantilever. These anharmonic signals can be understood with a model which goes beyond the common Hookian approximation: the cantilever is described as a multiple degree of freedom system. A theoretical analysis of the anharmonic signal...

We have developed a dynamic force microscope DFM working in a novel operation mode which is referred to as phase modulation atomic force microscopy PM-AFM . PM-AFM utilizes a fixed-frequency excitation signal to drive a cantilever, which ensures stable imaging even with occasional tip crash and adhesion to the surface. The tip-sample interaction force is detected as a change of the phase differ...

Three-dimensional molecular level images of uncoated human yon Willebrand factor (vWF), a plasma glyeoprotein, have been obtained using atomic force microscopy (AFM). However, the structural detail obtained by AFM was found to depend on the interactive forces between the hydrophilic mica surface and the vWF, relative to the tracking force of the probe tip acting on the protein, vWF on mica was ...

A commercially available atomic force microscopy and fluorescence microscope were installed and tested inside a custom-designed hyperbaric chamber to provide the capability to study the effects of hyperbaric gases on biological preparations, including cellular mechanism of oxidative stress. In this report, we list details of installing and testing atomic force microscopy and fluorescence micros...

Variation in the mechanical properties of a cell such as stiffness often provides little or no optical contrast when illuminated with light. Mechanical information is directly related to cell characteristics such as cell mobility, adherence or division and there is an interest in measuring these properties with the aim of revealing underlying mechanisms. Current methods for this purpose include...

The combination of atomic force microscopy (AFM) with single-molecule-sensitive confocal fluorescence microscopy enables a fascinating investigation into the structure, dynamics and interactions of single biomolecules or their assemblies. AFM reveals the structure of macromolecular complexes with nanometer resolution, while fluorescence can facilitate the identification of their constituent par...