The effect of long-term application of 4% atenolol eye drops has been studied in patients with either glaucoma or ocular hypertension. In some patients who show a good initial response the ocular hypotensive effect gradually wears off with long-term use. This pattern of response appears to be more frequent in patients with pretreatment intraocular pressure of 25 mmHg, or greater. In combination...

Rapid liquid chromatographic procedure has been developed for the simultaneous determination of Atenolol and Indapamide in a bulk drug and pharmaceutical formulation. The method uses C18 stationary phases and micellar mobile phases of 0.07M sodium dodecyl sulfate (SDS) pH 3 adjusted with phosphate buffer and 15% (v/v) 1propanol as organic modifier and ultraviolet detection at 229 nm are used fo...

The effect of once-daily atenolol, sustained-release oxprenolol (a new formulation of oxprenolol presented as a compressed tablet in a waxed matrix), and long-acting propranolol (a new formulation presented as spheriods in a capsule) was studied in a double-blind crossover trial in 23 carefully selected hypertensive outpatients. After a run-in period with matching placebo each patient received ...

Concerns have been raised regarding the postmarketing quality of generic drugs. This study assessed the pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol tablets in 24 healthy male volunteers in a single-dose, open, randomized, two-period crossover study under fasting conditions. Blood samples were collected for 24 h post dosing and assayed for atenolol using HPLC. B...

Multi-drug tablets of amlodipine besylate and atenolol were prepared as either mono-layer (mixed matrix) or bilayer tablets containing each drug in a separate layer by using similar excipients and processing. Each tablet batch was packed in strip and blister packs and kept under accelerated temperature and humidity conditions. The stability of two tablet and packaging types was compared by HPLC...

Hemodynamic (systemic and regional), metabolic and cardiovascular reflexive variables were measured before and after 4 weeks of beta blockade with atenolol in 10 patients with mild essential hypertension. Atenolol reduced mean arterial pressure, heart rate, cardiac index (all p less than 0.005) and renal vascular resistance (p less than 0.01) and increased total peripheral resistance (p less th...

The effect of enalapril was evaluated in 67 patients with essential hypertension, and its therapeutic efficacy was compared with atenolol in a placebo run-in, single-blind, cross-over trial. Enalapril significantly reduced blood pressure in all grades of essential hypertension. As monotherapy it 'normalized' blood pressure in 88%, 50% and 25% of patients with mild, moderate and severe hypertens...

Dr A E Fletcher, Department of Epidemiology and Population Sciences, London School ofHygiene and Tropical Medicine, London WC1E 7HT. atenolol, but in an observational study we cannot discount the possibility of confounding factors. Our model adjusted for the most obvious of these (age and smoking), but there may be other unidentified factors. The strength of experimental studies is that randomi...

AIM To replicate the genome-wide associations of the antihypertensive effects of bisoprolol and losartan in GENRES, using the Finnish patients of LIFE study. PATIENTS & METHODS We analyzed association of four SNPs with atenolol and three SNPs with losartan response in 927 Finnish LIFE patients (467 for atenolol and 460 for losartan). RESULTS rs2514036, a variation at a transcription start s...

In the present study a simple, accurate & precise reverse phase liquid chromatographic method has been developed & validated for simultaneous estimation of Atenolol & Indapamide from tablet dosage form. The method was developed using Waters HPLC system on a L1 column (Hypersil Gold: 250mm x 4.6 mm, 5μm) using a mixture of 0.1% Triethyl Amine in water of pH 3.0 & Methanol in the ratio 30:70 v/v ...