PURPOSE Anaplastic thyroid carcinoma (ATC) remains one of the most lethal known human cancers. Targeted molecular therapy with cetuximab, a monoclonal antibody against epidermal growth factor receptor, offers new treatment potentials for patient with ATC. Cetuximab has also been reported to have synergistic effects when combined with irinotecan, a topoisomerase inhibitor. Therefore, we hypothes...

BACKGROUND Mortality from trauma remains a major public health issue as it is the leading cause of death in persons aged 5 to 44 years. Uncontrolled hemorrhage and coagulopathy is responsible for over 50% of all trauma related deaths within the first 48 hrs of admission. Coagulation profiles are not routinely done among trauma patients in resource limited settings and there is a paucity of data...

With the high penetration of renewable energy resources, power systems are facing increasing challenges in terms flexibility and regulation capability. To address these, storage (ESSs) have been deployed on both transmission distribution systems. However, it is hard to coordinate these ESSs with a single centralized optimization, time-domain coupling constraints lead optimization complexity tim...

Linking RxNorm drugs to classes For MeSH, we extracted the PA relations from the MeSH data set and integrated them with RxNorm, in which the MeSH ingredients are already contained. There are 2,533 RxNorm ingredients with a PA relation. For ATC, we created a mapping at the ingredient level between ATC 5-level drugs and RxNorm. There are 2,441 RxNorm (salt or non-salt) ingredients (IN/PIN) with a...

The maximum power that can be transferred from one area to another area is called transfer capability. In 1996, North American Electric Reliability Council (NERC) established a framework for Available Transfer Capability (ATC) definition and evaluation. According to the NERC definition, ATC is the transfer capability remaining between two points above and beyond already committed uses (NERC, 19...

A RAMS (Reliability, Availability, Maintainability and Safety) document concerned with a brand new digital ATC (Automatic Train Control) system has been developed in proportion to IEC 62278. The ATC system is going to be applied for the most important commuter lines in the Tokyo Metropolitan Area in place of the present analog ATC system. East Japan Railway has taken a leading role in the safet...

This lecture is an introductory tutorial on the mechanics of implementing two methods for optimal system design: the individual disciplinary feasible approach (IDF), and analytical target cascading (ATC). Familiarity with optimization is assumed. A brief discussion on terminology is given, followed by an example-based introduction to both IDF and ATC. Additional references on IDF [1] and ATC [2...

Beth A. Tommasone, MS, ATC, and Tamara C. Valovich McLeod, PhD, ATC, CSCS, contributed to the conception and design; analysis and interpretation of the data; and drafting, critical revision, and final approval of the manuscript. Address correspondence to Tamara C. Valovich McLeod, PhD, ATC, CSCS, Athletic Training Program, Department of Interdisciplinary Health Sciences, Arizona School of Healt...