OBJECTIVES Asymptomatic hemorrhagic transformation (HT) is not associated with immediate deterioration of patients with acute ischemic stroke. However, it is unclear whether it is clinically innocuous with respect to long-term outcome. The aim of this study was to determine the impact of asymptomatic HT on 3-month outcome. METHODS A consecutive series of 1,618 patients, hospitalized between J...

OBJECTIVES The Asymptomatic Cardiac Ischemia Pilot (ACIP) study showed that revascularization is more effective than medical therapy in suppressing cardiac ischemia at 12 weeks. This report compares the relative efficacy of coronary angioplasty or coronary artery bypass graft surgery in suppressing ambulatory electrocardiographic (ECG) and treadmill exercise cardiac ischemia between 2 and 3 mon...

Background- The prevalence of ischemia and its prediction of events are unclear in outpatients with diabetes mellitus in the modern era of intensive medical management. We sought to identify the prevalence of ischemia, subsequent cardiac events, and impact of sex, stress type, and symptom status on these findings in a cohort of stable outpatients with diabetes mellitus referred for single-photo...

BACKGROUND AND PURPOSE We sought to determine the risks of stroke, myocardial ischemia, and vascular death in patients with asymptomatic carotid stenosis. METHODS Six hundred ninety-six patients with asymptomatic carotid stenosis referred to the Doppler laboratory were followed prospectively for a mean time of 41 months. These patients were studied both clinically and by carotid Doppler ultra...

BACKGROUND To report the rare association of peripheral retinal ischemia in a patient with Waldenström's macroglobulinemia. CASE PRESENTATION A 39-year old man with a recent diagnosis of asymptomatic Waldenström's macroglobulinemia (WM) was referred from his physician for ocular evaluation. The fundus examination in his right eye (RE) revealed very mild central vein dilation, while retinal he...

The clinical expression of vascular disease in the lower extremities of diabetics varies from asymptomatic to critical limb ischemia [1]. Ulcers and gangrene may develop, ultimately leading to amputation or even to death. In the diabetic population, the risk of vascular disease increases with age, duration of diabetes, and presence of peripheral neuropathy. The true prevalence of Peripheral Art...

BACKGROUND Increased blood and plasma viscosity, hematocrit, fibrinogen, and activation of coagulation and leukocytes have been reported in patients with claudication; however, their associations with symptomatic and asymptomatic peripheral arterial disease have not been reported in an epidemiological study. METHODS AND RESULTS Blood and plasma viscosity, hematocrit, fibrinogen, urinary fibri...

Peripheral artery disease (PAD) is often referred to as a continuum of disease of occlusive arterial syndromes that can range from asymptomatic obstructive disease through occlusive disease requiring amputation. This entire spectrum of PAD has prevalence as high as 20 % of the general population [ 1 ]. This spectrum becomes more progressive and symptomatic as the disease causes an imbalance of ...