The importance and increased demand of pharmaceutically active azaheterocycles has urged the development of inexpensive and environmentally benign catalytic asymmetric technologies. 2] In this context, the pyrazolidine and pyrazoline structural motif is present in several compounds with significant bioactivities, such as anti-inflammatory, antidepressant, anticancer, antibacterial and antiviral...

Approximately single-domain-sized 9-, 13-, and 16-nm CoFe2O4 nanoparticles are synthesized using the thermal decomposition of a metal-organic salt. By means of dilution and reduction, the concentration, moment, and anisotropy of nanoparticles are changed and their influence on the magnetic properties is investigated. The relation of M r/M s ∝ 1/lgH dip is observed, where M r/M s is the remanenc...

We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In particular, we detect drug binding in the proton transporter M2(18-60) from influenza A using recoupling experiments at room temperature and with cryogenic DNP. The results indicate that the pore binding site of rimantadine is...

Experimental characterization of one-bond heteronuclear dipolar couplings is essential for structural and dynamics characterization of molecules by solid-state NMR. Accurate measurement of heteronuclear dipolar tensor parameters in magic-angle spinning NMR requires that the recoupling sequences efficiently reintroduce the desired heteronuclear dipolar coupling term, fully suppress other interac...

A novel iterative procedure is described that allows both the orientation and dynamics of internuclear bond vectors to be determined from direct interpretation of NMR dipolar couplings, measured under at least three orthogonal alignment conditions. If five orthogonal alignments are available, the approach also yields information on the degree of motional anisotropy and the direction in which th...

We study the Fermi liquid properties of the cold atomic dipolar Fermi gases with the explicit dipolar anisotropy using perturbative approaches. Due to the explicit dipolar anisotropy, Fermi surfaces exhibit distortions of the dr2−3z2 type in three dimensions and of the dx2−y2 type in two dimensions. The fermion self-energy, effective mass, and Fermi velocity develop the same anisotropy at the H...

The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindolesvia a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophilewas described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(...

2. Analytical description of dipolar couplings in terms of molecular structure and dynamics . . . . . . . . . . . . . . . . . . 25 2.1. Incomplete averaging of the dipolar interaction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2.2. Structural dependence of residual dipolar couplings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

We report extensive numerical studies on plasmonic dimers of different configurations and find that their coupling effects can be categorized into three types of phenomena. First, like ordinary mechanical systems, the plasmonic dimers can exhibit positive couplings that show anti-crossing behavior. Second, they can also be arranged to exhibit negative couplings that display opposite trends in r...

Hyperpolarized (129)Xe can be used as a sensor to indirectly detect NMR spectra of heteronuclei that are neither covalently bound nor necessarily in direct contact with the Xe atoms, but coupled through long-range intermolecular dipole-dipole interactions. To reintroduce long-range dipolar couplings the sample symmetry has to be broken. This can be done either by using an asymmetric sample arra...