A model for the isotopic composition in .50 and .5 180 of ice formed by refreezing at the glacier sole is developed. This model predicts relatively well the distribution of points representing samples from basal layers of an Arctic a nd an Alpine glac ier on a .50.5 180 diagram . The frozen fraction which is the part of the liquid that refreezes can be determined for each basal ice layer. This ...

DNA topoisomerases (topos) and DNA polymerases (pols) are involved in many aspects of DNA metabolism such as replication reactions. We found that long chain unsaturated fatty acids such as polyunsaturated fatty acids (PUFA) (i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) inhibited the activities of eukaryotic pols and topos in vitro, and the inhibitory effect of conjugated fa...

In the mountains of Peru and Bolivia grows a plant so remarkable that, were you to read it for first time on April 1st, might believe yourself victim some botanical joke. A giant – far, far taller than all its neighbors flowers but once at end perhaps 100 years life. It was snippets information like these that led Italian-born Peruvian scientist geographer Antonio Raimondi set off in search 186...

still remember that brief moment that revealed the astonishment of everyone in the audience. Andrew Cleland had just concluded his talk at the conference ‘Quantum Optics of Nanoand Micromechanical Systems’, which was held last July in Bad Honnef, Germany. He had taken us all by surprise. Andrew’s talk had begun as a review of recent results of his and John Martinis’ team — they had achieved an ...

The voltage-gated proton channel, HV1, is notoriously unique among ion channels (1), and plays key roles in the health and disease of diverse tissues and species (2). Li et al. (3) combine biochemical, computational, and electron paramagnetic resonance (EPR) spectroscopic approaches to shed light on structural aspects of the human proton channel, hHV1. Their results advance the field in several...

Sitting on the edge of his bed, Anthony (played by Sir Hopkins) is wondering what happening in flat (figure). Unfamiliar people appear and then disappear. The changing too: “where are these from?” he asks, pointing at chairs, now also painting favourite daughter Lucy has disappeared. “Where she way?” (Actually, had died an accident.) He thinks losing all valuables. “Everyone's just helping them...

‘I remember standing with Bob Horvitz at the window of the old lecture room a year or so after we moved to Hinxton, looking at the enormous hole in the ground that was to be our new building. “John,” he asked me, “do you really know what you are doing?”’ Thus Sulston recalls one moment in the huge shift from being a researcher on the genetics and development of the worm Caenorhabditis elegans a...

For many years, I have helped to run an annual training day on management for young psychiatrists and psychologists who are about to become consultants. We usually spend most of the day doing an exercise where they turn themselves into the managing boards of two imaginary mental health institutions and compete for business. Over the years we have had fun inventing the names and characteristics ...

The term control is a loaded one and the term communication needs much clarification. In 1948 Wiener encapsulated the outcome of discussions about feedback loops and circular causality in self-regulating systems in his book Cybernetics: or Control and Communication in the Animal and the Machine and this was formally the beginning of cybernetics as a discipline. The name comes from the Greek for...

Digital Object Identifier: 10.1188/03.ONF.195 I had been talking recently with two of my best oncology nurse friends about two different but ultimately related topics. One called me to express her frustration about some television advertisements that for a time were airing frequently during prime time—ads for a drug that stimulates white blood cell production in patients receiving chemotherapy....