Heightened airway reactivity is a cardinal feature of asthma and correlates with many clinical features of the illness, such as the acute response to bronchodilator drugs, the magnitude of diurnal fluctuations in lung function, and the amount of therapy required to control symptoms. Data have accumulated indicating that a reduction in airway reactivity can decrease asthma morbidity, and many ad...

H1 receptor blocking antihistamines administered by mouth have not found a clear place in the management of bronchial asthma. We investigated the possibility that higher concentrations of these drugs, administered directly to the bronchial tree, might produce bronchodilatation. Twelve asthmatic patients inhaled aerosols generated from solutions of clemastine (0.05%), salbutamol (0.5%), and plac...

The prevalence of asthma is approximately 5% to 10% in the general population. Of these, approximately 5% to 10% are severe asthmatics who respond poorly to asthmatic drugs, including high-dose inhaled steroids. Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and severe airway obstruction even when taking high-dose inhaled steroids. The medical costs of treating sever...

BACKGROUND There is evidence that the bronchial microcirculation has the potential to contribute to the pathophysiological mechanisms of exercise induced bronchoconstriction (EIB) in asthmatic subjects. Vascular endothelial growth factor (VEGF), which is highly expressed in asthmatic airways, increases vascular permeability. The relationship between VEGF levels in induced sputum and the severit...

Milner, A. D., and Ingram, D. (1971). Archives of Diseases in Childhood, 46, 502. Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma. The bronchodilator and cardiac effects of 0-5% isoprenaline, 2 5% orciprenaline, and 0-5% salbutamol, and a placebo solution inhaled as a nebulized mist from a Wright nebulizer were compared with the help of 12 as...

Opiate addiction is an increasing social problem, and there has been a change from taking opiates intravenously to inhaling them in many areas of Britain. Three patients with asthma who required mechanical ventilation soon after heroin inhalation were described. Two subsequently died of acute severe asthma. The patients were reluctant to admit to their addiction and persisted inhaling heroin de...

Health[1] Health[1]Asthma [2]Bacteria [3]Body [4]Diseases [5]Denmark [6]Videnskab.dk [7] Antibiotics reduced the number of sick days caused by asthma attacks in young children by more than 50 per cent, shows new study. A small revolution could be about to the hit the market in the treatment of asthma attacks: Antibiotics reduce the number of sick days of asthmatic children aged one to three yea...

a third status Editor, As sometimes happens to asthmatic and epileptic patients, every now and then, a well controlled hypertensive patient also enters, for no apparent reason, a refractory hypertensive state that would demand urgent treatment with much higher doses of his usual medications and often with different and more powerful drugs to reverse it. In line with the nomenclature used for th...

Asthmatic subjects cough and bronchoconstrict to various agents known to stimulate sensory nerves. A population of sensory nerves, the C fibres, contain the neuropeptides substance P, neurokinin A (NKA), and calcitonin gene-related peptide (CGRP). Capsaicin, the principal ingredient of hot peppers, selectively stimulates C fibre afferents resulting in the release of these proinflammatory peptid...

Attention has recently been directed to the possible lethal effect of aerosol sympathomimetic agents in the treatment of bronchial asthma (Speizer, Doll, Heaf and Strang, 1968), death being attributed to an excitatory action on the heart. Animal studies indicate that practolol (I.C.I. 50,172, Eraldin) specifically blocks cardiac beta-adrenergic receptors, preventing arrhythmias or other alterat...