A programmable pre-assembly method is described and shown to produce near-infrared fluorescent molecular probes with tunable multivalent binding properties. The modular assembly process threads one or two copies of a tetralactam macrocycle onto a fluorescent PEGylated squaraine scaffold containing a complementary number of docking stations. Appended to the macrocycle periphery are multiple copi...

Kelvin probe force microscopy (KPFM) has provided deep insights into the local electronic, ionic and electrochemical functionalities in a broad range of materials and devices. In classical KPFM, which utilizes heterodyne detection and closed loop bias feedback, the cantilever response is down-sampled to a single measurement of the contact potential difference (CPD) per pixel. This level of deta...

Microbial cells are highly complex and heterogeneous systems. In general, cell populations contain subgroups of cells which exhibit differences in growth rate as well as resistance to stress and drug treatment [1]. In addition, individual cells are spatially organized and heterogeneous, and this cellular heterogeneity is used to perform key functions [2]. This complexity emphasizes the need for...

A new trifunctional probe, assembled using a cleavable linker, is useful for efficient enrichment and detection of alkynyl sugar-tagged biomolecules.

The aim of this work is to develop an experimental method to measure in-plane surface properties on the nanometer scale by torsional resonance mode atomic force microscopy and to understand the underlying system dynamics. The invention of the atomic force microscope (AFM) and the advances in development of new AFM based techniques have significantly enhanced the capability to probe surface prop...

abstract: the main aim of the vibration energy harvesters is to locally power autonomous devices such as wireless sensors. generally, power levels are low and the environmental benefit of the technology is to replace batteries rather than saving energy per se. piezoelectric vibrational energy harvesters are usually inertial mass based devices, where a cantilever beam with a piezoelectric outer ...

Title of Dissertation: NANOMECHANICAL RESONATORS TOWARDS SINGLE SPIN SENSITIVITY Harish Bhaskaran, Doctor of Philosophy, 2006 Directed By: Professor Keith Schwab Department of Physics Ultrasensitive force detectors are required for progress towards single atom imaging using magnetic resonance force microscopy (MRFM). MRFM is a scanned probe imaging technique, with potential for atomic-scale, no...

Single and multi-walled carbon nanotubes (CNT) have been described as ideal tips for atomic force microscope (AFM) microcantilevers. They offer high spatial resolution, excellent wear resistance, the ability to image high aspect ratio semiconductor trenches, and possess a low bending stiffness which allows imaging of soft biomolecules with reduced contact forces. The objective of the current re...

The adhesive pads of geckos provide control of normal adhesive force by controlling the applied shear force. This frictional adhesion effect is one of the key principles used for rapid detachment in animals running up vertical surfaces. We developed polypropylene microfiber arrays composed of vertical, 0.3 μm radius fibers with elastic modulus of 1 GPa which show this effect for the first time ...

Cantilevers fabricated by means of micromachining techniques are usually used for atomic force microscopy. In this paper, the spring constant of an atomic force microscope (AFM) cantilever is determined by using a large-scale cantilever. Since the spring constant of the large-scale cantilever is calibrated accurately, the spring constant of the AFM cantilever is determined precisely by measurin...