Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.

The aim of this work is to present the numerical results influenza disease nonlinear system using feed forward artificial neural networks (ANNs) along with optimization combination global and local search schemes. genetic algorithm (GA) active-set method (ASM), i.e., GA-ASM, are implemented as mathematical dependent four classes, susceptible S(u), infected I(u), recovered R(u) cross-immune indi...

Anterior sacral meningocele (ASM) is a rare congenital anomaly, characterized by herniation through a defect in the anterior aspect of the sacrum. We reported a case of ASM associated with neurofibromatosis, which was mimicking a complex ovarian cyst in ultrasonography. ASM can easily be misdiagnosed as an ovarian cyst and needle aspiration can cause intracranial hypotension syndrome or even de...

We quantified the effects of airway wall remodeling upon airway smooth muscle (ASM) shortening. Isolated ASM from sheep was attached to a servo-controller that applied a physiologic load. This load could be altered to reflect specified changes of airway wall geometry, elasticity, parenchymal tethering, transpulmonary pressure (P(L)), and fluctuations in P(L) associated with breathing. Starting ...

Airway remodeling, including increased airway smooth muscle (ASM) mass, is a hallmark feature of asthma and COPD. We previously identified the expression of bitter taste receptors (TAS2Rs) on human ASM cells and demonstrated that known TAS2R agonists could promote ASM relaxation and bronchodilation and inhibit mitogen-induced ASM growth. In this study, we explored cellular mechanisms mediating ...

The present study aimed to establish an effective method for the in vitro culture of guinea pig airway smooth muscle (ASM) cells, and also investigate the suppressive effect of mabuterol hydrochloride (Mab) on the increased level of intracellular Ca2+ in ASM cells induced with acetylcholine (Ach). Two different methods, i.e. with or without collagenase to pretreat tracheal tissues, were applied...

The aim of this paper is to demonstrate the evaluation process select Aerosol Suction Machine (ASM) design be implemented in a dental treatment practice prevent spread COVID-19. There are two designs evaluated, movable ASM and fixed mounting ASM. involved four criteria: flexibility, safety level, manufacturability, maintenance. conducted based on specific requirement small clinic located Suraka...

Abstract We investigate the decades-long X-ray variations in bright low-mass binaries containing a neutron star (NS-LMXBs). The light curves of MAXI/GSC and RXTE/ASM cover ∼26 yr, high-quality are obtained from 33 NS-LMXBs. Among these, together with Ginga/ASM, two sources (GX 3+1 GX 9+1) showed an apparent sinusoidal variation respective periods ∼5 ∼10 yr 34 curve. Their luminosities were (1–4...

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) channels and metabotropic (GABA(B)) receptors. GABA(A) channels are ubiquitously expressed in neuronal tissues, and in mature neurons modulate an inward chloride current resulting in neuronal inhibition due to membrane hyperpolariza...