Abstract Current guidelines advocate to treat refractory status epilepticus (RSE) with continuously administered anesthetics induce an artificial coma if first- and second-line antiseizure drugs have failed stop seizure activity. A common surrogate for monitoring the depth of is appearance a burst-suppression pattern (BS) in EEG. This review summarizes current knowledge on origin neurophysiolog...

BACKGROUND In vitro studies suggest that antimicrobial activity of antibiotics meant to treat central nervous system infections such as meningitis or ventriculitis may be altered by cerebrospinal fluid (CSF). This could explain the reason behind the often observed discrepancies between the activity of antibiotics determined in artificial growth media in vitro, and their sometimes reduced clinic...

The year 1882 was an annus mirabilis in the history of pulmonary tuberculosis, for it saw not only the discovery of the tubercle bacillus by Robert Koch but also the introduction of artificial pneumothorax treatment by Carlo Forlanini. At that time Koch's spectacular achievements and the exaggerated expectations raised after the introduction of tuberculin tended to overshadow the significance o...

The paper gives an overview of the meaning of Artificial Intelligence, (AI) Advantages and disadvantages. There are several fields in AI-robotics, speech recognition and expert system-to name a few. Doing the laundry or the dishes may no longer seem a chore. Robots are programmed to perform these activities. The recent times saw the artificially developed robot “Eve” help in searching for new d...

The drug discovery and development process is lengthy and expensive, and bringing a drug to market may take up to 18 years and may cost up to 2 billion $US. The extensive use of computer-assisted drug design techniques may considerably increase the chances of finding valuable drug candidates, thus decreasing the drug discovery time and costs. The most important computational approach is represe...

Dry eye syndrome (DES, Keratoconjunctivitis sicca) is a common disorder of the tear film caused by decreased tear production or increased evaporation. Changes in tear composition also promote inflammation on the ocular surface by various mechanisms. Artificial tear drops, tear retention treatment, stimulation of tear secretion, or anti-inflammatory drugs may be used for dry eye treatment accord...

BACKGROUND The purpose of this study was to develop a sustained drug-release model for water-soluble drugs using silica nanoparticles. METHODS Hollow-type mesoporous silica nanoparticles (HMSNs) were prepared using Na(2)CO(3) solution as the dissolution medium for the first time. The water-soluble compound, silybin meglumine, was used as the model drug. The Wagner-Nelson method was used to ca...

The importance of online recommender systems for drugs, medical professionals, and hospitals is growing. Today, the majority people use consultations drug recommendations all types health issues. Emergencies such as pandemics, floods, or cyclones can be helped by system. In era machine learning (ML), produce more accurate, quick, reliable clinical predictions with minimal costs. As a result, th...

Paeoniae Radix is one of the crude drugs frequently used in traditional Japanese medicine (Kampo medicine). It takes abundant labor and time to cultivate Paeonia lactiflora for medicinal use; high production cost is one of the main reasons why the domestic production of Paeoniae Radix is decreasing in Japan. To promote the production of Paeoniae Radix, we focused on Paeonia cultivars that produ...