Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggest...

BACKGROUND Presently, there are no approved nonoperative therapies for the ongoing treatment of persistent shoulder pain. Preliminary data suggest that intra-articular sodium hyaluronate injections may be beneficial for the treatment of persistent shoulder pain resulting from various etiologies. The present study evaluated the efficacy and safety of sodium hyaluronate (Hyalgan; molecular weight...

INTRODUCTION Hypoxia is a feature of the inflamed synovium in rheumatoid arthritis (RA). Intra-articular injection of hyaluronan (HA) may be considered a potential way to treat RA. However, the exact molecular mechanism of HA on decreased cellular responses to hypoxic environment is unclear. The present study has been designed to use the adjuvant-induced arthritis model to examine the effects o...

We evaluated and compared the effectiveness of intra-articular injection of hip joint using hyaluronic acid and steroid in patients with femoroacetabular impingement (FAI). Thirty patients with FAI clinically and radiologically were enrolled and underwent hip injection using steroid (TA) or hyaluronic acid (HA) at 0-weeks with cross-over injection at 2-weeks in patients without clinical respons...

knee surgery. the purpose of this study was to assess the analgesic effects of intra-articular injection of a dexmedetomidine following knee arthroscopy. methods:   forty six patients schadualed for arthroscopic knee surgery under general anaesthesia, were randomly devided into two groups. intervention group received 1μg/kg dexmedetomidine (d) and isotonic saline. control group received 25ml is...

Experiments were carried out on anesthetized adult New Zealand rabbits. Acute joint inflammation was achieved by intra-articular injection of 2% carrageenan. Radiolabelled microspheres were used to measure the effect of acute inflammation on blood flow in the knee joint and establish whether neural influences on blood vessel caliber were affected. Surgical exposure of the posterior joint "capsu...

INTRODUCTION Clinical trials provided controversial results on whether the injection of hyaluronan preparations into osteoarthritic joints reduces pain. Problems of clinical studies may be the substantial placebo effects of intra-articular injections, different severity and rate of progression of the disease and others. We hypothesize that the use of preclinical pain models may help to clarify ...

Background: Primary gonarthrosis is a progressive disease that increases with age and leads to limitations in activities of daily living. Until surgery performed, nonsteroidal anti-inflammatory drugs, intraarticular injections, physical therapy methods are used.
 Purpose: This study aims compare the clinical outcomes intra- articular corticosteroid (CCS) hyaluro nic acid (HA) injections fo...