Methyl Bromide under Fire Methyl bromide is one of the most widely used pesticides in the world, a broad-spectrum fumigant effective in controlling insects, nematodes, fungi, and bacteria. Methyl bromide is also highly toxic to humans. In December 1993, the EPA listed methyl bromide as a stratospheric ozone-depleting substance subject to phase-out. The final rule, issued 1 January 1994, freezes...

BACKGROUND AND AIM Long-acting bronchodilators are the mainstay of pharmacological treatment for patients with chronic obstructive pulmonary disease (COPD). The aim of this review is to provide an overview of the clinical studies evaluating the safety and efficacy of inhaled aclidinium bromide, a novel long-acting anticholinergic bronchodilator, for the treatment of COPD. METHOD This systemat...

In chronic obstructive pulmonary disease (COPD) patients tiotropium bromide has been shown to improve forced expiratory volume in one second (FEV1) and inspiratory capacity (IC). We investigated whether the mechanism leading to these improvements is related to small airways ventilation heterogeneity, assessed by multiple breath washout tests. Forty stable tiotropium-free COPD patients (FEV1: 27...

Galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana roots, was investigated for its potentiating effect on the antimicrobial activity of antibiotics as well as ethidium bromide, in 6 multidrug resistance (MDR) clinical isolates of Staphylococcus aureus. Galbanic acid had inhibitory effect on none of the isolated bacteria tested (up to 800 μg /ml). The MIC range of ciprofloxacin, tet...