Two studies have recently shown a clear benefit of using nonsteroidal aromatase inhibitors (AIs) in combination with growth hormone (rhGH) in pubertal boys of very short stature (between -2.5 and 3 SDS) who are approaching the end of their growth [1,2]. AIs have been used in human therapeutics since the 1990s, mostly in adults [3], to block aromatase by binding to the heme iron of aromatase, a ...

MCF-7 cells transfected with human placental aromatase gene (MCF 7Ca cells) or cells transfected with plasmid vector only (MCF-7Cc cells) were inoculated into nude mice with MatrigeL Tumors formed from both MCF.7Ca and MCF.7Cc cells grew faster in intact mice than In ovariec tomized mice, suggesting that the tumors maintained their responsiveness to estrogen stimulation and that their growth wa...

Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New A,D-ring modified steroid analogues of formestane and testolactone were designed and synthesized and their biochemical activity was investigated in vitro in an attempt to find new aromatase inhibitors and to gain insight into their structure-activity relationships (SAR). All compounds tested ...