Over time, the epidemiologic and demographic characteristics of AIDS have changed in the United States, while the use of highly active antiretroviral therapy has changed the natural history of the disease. The goal of the study was to ascertain any changes in the epidemiologic, immunologic, pathologic, or clinical characteristics of AIDS-related lymphoma (ARL) over the course of the AIDS epidem...

Risk-adjusted CUSUM schemes are designed to monitor the number of adverse outcomes following a medical procedure. An approximation of the average run length (ARL), which is the usual performance measure for a risk-adjusted CUSUM, may be found using its Markov property. We compare two methods of computing transition probability matrices where the risk model classifies patient populations into di...

The objective of this research is to select the appropriate control charts for detecting a shift in the autocorrelated observations. The autocorrelated processes were characterized using AR (1) and IMA (1, 1) for stationary and non-stationary processes respectively. A process model was simulated to achieve the response, the average run length (ARL). The empirical analysis was conducted to quant...

Despite highly active antiretroviral therapy (HAART), AIDS related lymphoma (ARL) occurs at a significantly higher rate in patients infected with the Human Immunodeficiency Virus (HIV) than in the general population. HIV-infected macrophages are a known viral reservoir and have been shown to have lymphomagenic potential in SCID mice; therefore, there is an interest in determining if a viral com...

ATP is thought to be released to the extracellular compartment by neurons and astrocytes during neural activation. We examined whether ATP exerts its effect of promoting pial arteriolar dilation (PAD) directly or upon conversion (via ecto-nucleotidase action) to AMP and adenosine. Blockade of extracellular direct ATP to AMP conversion, with ARL-67156, significantly reduced sciatic nerve stimula...

The small ciliary G protein Arl13b is required for cilium biogenesis and sonic hedgehog signaling and is mutated in patients with Joubert syndrome (JS). In this study, using Caenorhabditis elegans and mammalian cell culture systems, we investigated the poorly understood ciliary and molecular basis of Arl13b function. First, we show that Arl13b/ARL-13 localization is frequently restricted to a p...

We address the problem of online change detection in multivariate datastreams, and we introduce QuantTree Exponentially Weighted Moving Average (QT-EWMA), a nonparametric change-detection algorithm that can control expected time before false alarm, yielding desired Run Length (ARL$_0$). Controlling alarms is crucial many applications rarely guaranteed by algorithms monitor datastreams without k...

Resumen. En la actualidad, el uso de las redes sociales ha revolucionado la forma en que los usuarios intercambian ideas, opiniones e información. Gracias a este cambio de paradigma en la forma de interactuar entre los usuarios, las grandes compañ́ıas y personajes públicos han comenzado a prestar particular interés a la opinión generada respecto a sus productos y/o servicios, actos y/o eventos d...

Soon after joining the Signal Processing Group of Army Research Laboratory in Adelphi, Maryland (ARL-Adelphi), in 1983, I happened to be walking down one of the many hallways of ARL-Adelphi when somehow I met up with Howard Brandt. After a brief exchange of the usual initial greetings, our conversation turned to a discussion of his research work in relativity. I soon learned that his research w...

27 28 29 Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be 30 crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and