AIMS Lynch Syndrome is caused by mutations in DNA mismatch repair (MMR) genes. Mutation carrier identification is facilitated by immunohistochemical detection of the MMR proteins MHL1 and MSH2 in tumour tissue and is desirable as colonoscopic screening reduces mortality. However, protein detection by conventional immunohistochemistry (IHC) is subjective, and quantitative techniques are required...

Authors' A Nat iona l Immunolo Immunopa National C Immunizati Note: Curre Rica Unive Correspon miology Br Cancer Ins 20852. Pho nih.gov

Background and Objectives: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy. In case of early detection, some of its complications can be prevented. The aim of this study was to investigate early prediction of GDM by logistic regression (LR), discriminant analysis (DA), decision tree (DT) and perceptron artificial neural network (ANN) and to compare these m...

Ranking measures play an important role in model evaluation and selection. Using both synthetic and real-world data sets, we investigate how different types and levels of noise affect the area under the ROC curve (AUC), the area under the ROC convex hull, the scored AUC, the Kolmogorov-Smirnov statistic, and the H-measure. In our experiments, the AUC was, overall, the most robust among these me...

OBJECTIVE In lung transplantation, appropriate size matching is of crucial importance to achieve satisfactory outcomes. Tailoring of the lung has been repeatedly described as successful means of overcoming size disparities. The goal of this study was to define a parameter helping the surgeon in the decision whether a standard lung transplantation or a lobar transplantation should be anticipated...

BACKGROUND AND OBJECTIVE Patients with persistent asthma have different inflammatory phenotypes. The electronic nose is a new technology capable of distinguishing volatile organic compound (VOC) breath-prints in exhaled breath. The aim of the study was to investigate the capacity of electronic nose breath-print analysis to discriminate between different inflammatory asthma phenotypes (eosinophi...

Disease prevention is important and can be accomplished by developing diagnostic tests. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) are used to assess the accuracy of diagnostic tests. The assessment for the superiority between evaluating two diagnostic tests is needed when comparing two diagnostic tests. Existing tests are constructed by comparing t...

A local linear method for estimating the conditional ROC curve under the presence of continuous and categorical covariates has been introduced in this paper. A data driven smoothing parameter has been proposed via the bootstrap method. The methods have been illustrated with real data coming from a discrimination problem emerging in the context of a computer-aided diagnosis system. The bootstrap...