The 14 allele of the apolipoprotein E gene constitutes the major genetic risk factor to develop Alzheimer’s disease. If and how this protein contributes to the pathological cascade of Alzheimer’s disease is not known. The 14 allele particularly affects the cholinergic defect, which is one of the most consistent neurotransmitter problems in an Alzheimer’s disease brain. We have analysed several ...

This review assesses current knowledge of the clinical, genetic, and biochemical features of familial high density lipoprotein (HDL) deficiency syndromes. The focus is on HDL deficiency states occurring in the absence of severe hypertriglyceridemia or lecithin/cholesterol acyltransferase deficiency. Specific entities falling within this category include Tangier disease, familial HDL deficiency ...

This study was conducted to investigate the effects of dietary curcumin on hepatic lipid metabolism and antioxidant capacity in Roman laying hens. A total 144 hens (28 weeks old) were allocated 4 treatments that included at concentrations 0, 50, 150, 250 mg/kg for 9 weeks. Each treatment had 6 replicates per group with replicate (2 birds/cage). The results showed supplementation decreased (P < ...

References 1. Willems Van Dijk K, Rensen PC, Voshol PJ, Havekes LM. The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism. Curr Opin Lipidol 2004;15:239–46. 2. Pennacchio LA, Rubin EM. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler Thromb Vasc Biol 2003;23:529–34. 3. Pennacch...

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein E ɛ4 carriers decades before the onset of Alzheimer's disease. The goal of this study was to determine whether early intervention using rapamycin could restore neurovascular and neurometabolic functions, and thus impe...

We examined the relationship between maternal smoking during pregnancy and serum lipid, lipoprotein and apolipoprotein levels in newborns. Serum concentrations of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B and lipoprotein (a) were assessed in blood samples from 38 mothers who were smokers and t...

OBJECTIVE The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia. METHODS ...