Objective: To evaluate, industry independently, the accuracy of the Watch-PAT100 system (WP100) [Itamar Medical; Caesarea, Israel], a portable home sleep test, compared to polysomnography, the gold standard for diagnosing obstructive sleep apnea syndrome. Methods: Prospective clinical trial. 27 patients (24 male, 3 female) were evaluated at our institution's sleep laboratory. The apnea hypopnea...

BACKGROUND An animal model mimicking all the factors involved in obstructive sleep apnea (OSA) is useful for investigating mechanisms because the associated comorbidity usually present in such patients is an important limitation. AIM To test the hypothesis that hypoxia/normoxia and respiratory effort have different effects on the induction of inflammatory response and endothelial dysfunction ...

introduction: sleepiness may predispose drivers to road traffic accidents. obstructive sleep apnea syndrome is the most common medical cause of sleepiness. hence increased neck circumference (nc) and obesity are known as obstructive sleep apnea syndrome risk factors. this study was conducted to assess osas role in occurrence of road traffic accidents in sleeping drivers of commercial heavy vehi...

many premature neonates suffer from apnea, and aminophylline is administrated for them. the objective of this study was to reveal pharmacokinetic (pk) parameters of theophylline in iranian premature neonates. premature neonates (68) who were admitted in the neonatal intensive care unit (nicu) of namazi, hafez, and zeinabieh hospitals were included in the study. all of them received 5 mg/kg amin...

399 B oth sleep apnea and congestive heart failure are common disorders. However, systolic heart failure appears to be the most common cause of central and perhaps obstructive sleep apnea. Obstructive sleep apnea is also common in isolated diastolic heart failure and may contribute to the progression of left ventricular remodeling and perhaps play a causative role. 1,3-6 However, prevalence and...

STUDY OBJECTIVES Sleep apnea is common in patients with congestive heart failure, and may contribute to the progression of underlying heart disease. Cardiovascular and metabolic complications of sleep apnea have been attributed to intermittent hypoxia. Elevated free fatty acids (FFA) are also associated with the progression of metabolic, vascular, and cardiac dysfunction. The objective of this ...

OBJECTIVE CHARGE syndrome occurs in approximately 1 in 8500 live births and is diagnosed clinically by combinations of major characteristics: choanal atresia, coloboma, characteristic ears, cranial nerve abnormalities and distinct temporal bone anomalies. More than 50% of children with CHARGE syndrome experience sleep disturbances, with obstructive sleep apnea being one diagnosis. Objectives of...

OBJECTIVE To determine the effect of tracheotomy on polysomnographic and arterial blood gas data in patients with obstructive sleep apnea (OSA). DESIGN A retrospective study of all patients who underwent tracheotomy and were studied polysomnographically at the Johns Hopkins Sleep Disorders Center, Baltimore, Md, since 1981. SETTING A regional sleep disorders center. PATIENTS Twenty-eight ...

This study offers a literature research reference value for bioengineers and practitioner medical doctors. It could reduce research time and improve medical service efficiency regarding Obstructive Sleep Apnea (OSA) detection systems. Obstructive Sleep Apnea (OSA) is a sleeping disorder characterized by the repetitive reduction of airflow during sleep. Much of the past and the current apnea res...

To investigate the contribution of the peripheral chemoreceptors to the susceptibility to posthyperventilation apnea, we evaluated the time course and magnitude of hypocapnia required to produce apnea at different levels of peripheral chemoreceptor activation produced by exposure to three levels of inspired P(O2). We measured the apneic threshold and the apnea latency in nine normal sleeping su...